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The major interest of my lab is to study microRNA (miRNA) expression differences between schizophrenic (SZ) and bipolar (BP) patients and healthy controls. MiRNAs are small RNA species which primarily function to negatively regulate gene expression. Using Taqman low density arrays (TLDA), we have identified significantly differentially expressed miRNAs in both SZ and BP subjects. Furthermore, using a RNP immunoprecipitation-microarray (RIP-ChIP) approach, we have identified multiple subsets of mRNA targets for these disease related miRNAs. Some of these mRNA targets are co-regulated on transcriptional as well as translational levels and might have related functions in disease development. The significance of these findings is based on the fact that the miRNAs themselves, not their target genes, should be considered as liability factors for disease development.
In addition to miRNAs, my lab also focuses on the genetic control of global gene expression. Recent studies have used genome-wide association studies (GWAS) to discover genes that are associated with complex psychiatric illnesses such as alcoholism, schizophrenia or bipolar disorders. Although such studies are important in narrowing the potentially causative genes, they tell us little about the molecular mechanisms by which these genes cause or modulate disease development. Thus, using post-mortem brain samples, the research in my lab is focused on studying the genetic and molecular mechanisms of gene expression in the development of schizophrenia, bipolar disorders and alcoholism. More specifically, gene expression changes in brain are assessed through medium to high-throughput technologies such as Taqman Low density arrays (TLDA), expression based microarrays and massive parallel signature sequencing (MPSS), all of which allow for an unbiased, global quantitation of all transcripts within the neuronal cells. Next, using genome-wide genotypic data, we can identify a potential disease- relevant expression quantitative trait loci (eQTL) which would provide a direct link between disease-associated genetic variants (e.g. SNPs) or epi-genetic (e.g. methylation) modifications and gene expression changes.
Lee D; Bigdeli TB; Williamson VS; Vladimirov VI; Riley BP; Fanous AH; Bacanu SA, 2015. DISTMIX: Direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts.  Bioinformatics.
Lee D; Williamson VS; Bigdeli TB; Riley BP; Fanous AH; Vladimirov VI; Bacanu SA, 2015. JEPEG: a summary statistics based tool for gene-level joint testing of functional variants.  Bioinformatics 31(8):1176-82
Williamson VS; Mamdani M; McMichael GO; Kim AH; Lee D; Bacanu S; Vladimirov VI, 2015. Expression quantitative trait loci (eQTLs) in microRNA genes are enriched for schizophrenia and bipolar disorder association signals.  Psychol Med.
Savage JE; McMichael O; Gorlin EI; Beadel JR; Teachman B; Vladimirov VI; Hettema JM; Roberson-Nay R, 2015. Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.  Biol Psychol 109:61-66
Schultz CC; Nenadic I; Riley B; Vladimirov VI; Wagner G; Koch K; Schachtzabel C; Mühleisen TW; Basmanav B; Nöthen MM; Deufel T; Kiehntopf M; Rietschel M; Reichenbach JR; Cichon S; Schlösser RG; Sauer H, 2014. ZNF804A and cortical structure in schizophrenia: in vivo and postmortem studies.  Schizophr Bull 40(3):532-41
White S; Acierno R; Ruggiero KJ; Koenen KC; Kilpatrick DG; Galea S; Gelernter J; Williamson V; McMichael O; Vladimirov VI; Amstadter AB, 2013. Association of CRHR1 variants and posttraumatic stress symptoms in hurricane exposed adults.  J Anxiety Disord 27(7):678-83
Mamdani M; McMichael GO; Gadepalli V; Williamson V; Parker EK; Haroutunian V; Vladimirov VI, 2013. Differential regulation of schizophrenia-associated microRNA gene function by variable number tandem repeats (VNTR) polymorphism.  Schizophr Res 151(1-3):284-6
Kim AH; Parker EK; Williamson V; McMichael GO; Fanous AH; Vladimirov VI, 2012. Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.  Schizophr Res 141(1):60-4
McClay JL; Adkins DE; Aberg K; Stroup S; Perkins DO; Vladimirov VI; Lieberman JA; Sullivan PF; van den Oord EJ, 2011. Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.  Mol Psychiatry 16(1):76-85
Maher BS; Vladimirov VI; Latendresse SJ; Thiselton DL; McNamee R; Kang M; Bigdeli TB; Chen X; Riley BP; Hettema JM; Chilcoat H; Heidbreder C; Muglia P; Murrelle EL; Dick DM; Aliev F; Agrawal A; Edenberg HJ; Kramer J; Nurnberger J; Tischfield JA; Devlin B; Ferrell RE; Kirillova GP; Tarter RE; Kendler KS; Vanyukov MM, 2011. The AVPR1A gene and substance use disorders: association, replication, and functional evidence.  Biol Psychiatry 70(6):519-27
Aberg K; Adkins DE; Bukszár J; Webb BT; Caroff SN; Miller DD; Sebat J; Stroup S; Fanous AH; Vladimirov VI; McClay JL; Lieberman JA; Sullivan PF; van den Oord EJ, 2010. Genomewide association study of movement-related adverse antipsychotic effects.  Biol Psychiatry 67(3):279-82
Kim AH; Reimers M; Maher B; Williamson V; McMichael O; McClay JL; van den Oord EJ; Riley BP; Kendler KS; Vladimirov VI, 2010. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.  Schizophr Res 124(1-3):183-91
Vladimirov VI; Maher BS; Wormley B; O'Neill FA; Walsh D; Kendler KS; Riley BP, 2009. The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.  Schizophr Res 107(2-3):249-54
Thiselton DL; Vladimirov VI; Kuo PH; McClay J; Wormley B; Fanous A; O'Neill FA; Walsh D; Van den Oord EJ; Kendler KS; Riley BP, 2008. AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families.  Biol Psychiatry 63(5):449-57
Vladimirov VI; Laktionova AI; Polushina ND, 2004. [Drinking mineral waters in rehabilitation of cancer patients].  Vopr Kurortol Fizioter Lech Fiz Kult.
Vladimirov VIu; Babakhanian AR, 2003. [Forensic, medical, and criminalistic description of injuries inflicted by firing the pistol "PB-4"].  Sud Med Ekspert 46(4):17-8
Polushina ND; Vladimirov VI; Frolkov VK, 2002. [Effect of drinking mineral water on hormonal regulation of glucose homeostasis after mastectomy for breast cancer].  Vopr Kurortol Fizioter Lech Fiz Kult.
Vladimirov VI; Polushina ND; Frolkov VK; Efimenko NV, 1999. [The correction of the hormonal response during the treatment of the dumping syndrome with potable mineral waters].  Vopr Kurortol Fizioter Lech Fiz Kult.
Zueva LP; Iafaev RKh; Vladimirov VI; Afinogenov GE, 1986. [Characteristics of the sources and routes of spread of a Pseudomonas aeruginosa infection in a trauma department].  Zh Mikrobiol Epidemiol Immunobiol.
Gilevich MIu; Movsesov AS; Vladimirov VI, 1983. [Treatment of echinococcosis with rare localization].  Vestn Khir Im I I Grek 130(1):132-8
VLADIMIROV VI, 1952. [Anticoagulant dicoumarin and its practice significance].  Ter Arkh 24(6):70-82
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