Multivariate Genetic Modeling

Time Speaker Topic Presentation Notes/Examples
09:00 – 10:00 Kenneth Kendler Statistical Genetics of Substance Use Introduction
10:00 – 10:30 Timothy York / Michael Neale Review 1: R & OpenMx Gen Epi Helper Functions
R_Introduction.R
11:00 – 12:30 Hermine Maes / Elizabeth Prom Review Multivariate Genetic Factor Analysis ReviewMultivariatr
Carey BG 1988
twinMulAceOrd.RselVATSma.dat
twinCCCAceOrd.RselVATSird.dat
01:30 – 02:30 Nathan Gillespie / Brad Verhulst Direction of Causation DirectionOfCausation
Lee 2012 Correlation-Causation
Lee 2012 Commentary
DOC_continuous.R
03:00 – 04:00 Michael Neale / Hermine Maes Comorbidity Comorbidity altform.R
bivariateBinaryACE.R
bivariateBinaryACENoCon.R
directionofCausation.R
randomMultiformity.R
threeDisorders.R
readffpairs.R
ffpairs.rec
runAll.R
comorbPlot.R

Measurement & Phenotyping

Time Speaker Topic Presentation Notes/Examples
08:00 – 09:00 Sarah Medland Threshold Modeling TuesdayMorning
DataPreparation
threshold.R
thresholds
twinAceBin-Traditional.R
twinAceOrd-Traditional.R
twinAceBin-FixE.R
twinAceOrd-FixE.R
twinAceOrd-FixThresholds.R
two_cat.dat
09:00 – 10:30 Michael Neale / Shuanna Clark Measurement Invariance / Underreporting MeasurementInvariance MIExample.R
octomult_10aug2010.rdata
11:00 – 12:30 Ryne Estabrook / Nathan Gillespie Factor Scores/ Item Response Model FactorScoringAndIRT factorScores.R
fsData.txt
transformFactorScores.R
trueFactorScores
01:30 – 03:30 Shaunna Clark / Ryne Estabrook Latent Class Analysis/Factor Mixture Model Crosssectional_Mixture Data_Oz_CAN_Sim.dat
LCA_example.R
LCA_2Classes.Rdata
LCA_example_3c.R
LCA_3Classes.Rdata
LCA_example_4c.R
LCA_4Classes.Rdata
LCAdata.R

Genes, Environment & Development

Time Speaker Topic Presentation Notes/Examples
08:00 – 09:00 Sarah Medland WednesdayMorning
MatrixAlgebraHandout
twinACE.R
twinACECovSex.R
twinACECovSexAge.R
prepearlier
09:00 – 10:30 Mehta / Michael Neale Hierarchical Mixed Modeling ML-SEMinBehavioralGenetics nLevelSEM-APracticalIntroduction
11:00 – 12:30 Nathan Gillespie / Lindon Eaves Latent Growth Curve Modeling LGC_modeling LGC_ordinal.R
LGC_continuous.R
growth
polychoricFunctionSim
01:30 – 3:00 Shuanna Clark / Ryne Estabrook Growth Mixture Modeling, Regime Switching GrowthMixtureModeling GMM_example.R
growth

Family Processes

Time Speaker Topic Presentation Notes/Examples
08:00 – 09:00 Sarah Medland ThursdayMorning
Ordinal
twinACE.R
twinAceOrd-FixThresholds.R
09:00 – 10:00 Lindon Eaves / Hermine Maes Twin-Family and Extended Pedigrees ExtendedTwinKishipDesigns
AGESSiblingSpouseInteraction
Siblings.R
10:00 – 10:30 Hermine Maes / Lindon Eaves Nuclear Family, COT, ET MLcorrelations
ETdesigns
Et88-P.R
MZM
DZM
MZF
DZF
DZO
ET88-P2.R
ETdata.txt
11:00 – 12:30 Brad Verhulst / Sarah Medland Sibling Models and Age Difference Moderation ModeratingCovariance TaSsim1.R
TaSdata
TaSmod.R
ModGraph.R
01:30 – 03:00 Brad Verhulst Building Models from Scratch ACE example.R

GxE Interaction

Time Speaker Topic Presentation Notes/Examples
08:00 – 09:00 Sarah Medland VCxEnvSimulatedSTUDENT.R
GxEdata
09:00 – 10:30 Lindon Eaves / Timothy York / Sarah Medland Genotype Environment Interaction GxE_Interaction
Purcell_2002
Purcell & Sham_2002
Medland_2009
Nature Letter 2012
binaryGE.R
GxEdata
ordinalGE.R
continuous_rGE.R
binaryGE_CI_wrong.R
badCIs
binaryGE_CI_correct.R
goodCIs
11:00 – 12:30 Tim Bates / Hermine Maes / Elizabeth Prom Measured & Unmeasured GxE Interaction SEM_Measured_Genotypes UnivTwinACEGOrdExP.R
selVATS.dat
01:30 – 03:00 Lindon Eaves / Michael Neale Model Limitations SummaryNIDA_AGES_Workshop LCA_ExampleSeparateItemsPlanB.R