Contact Information

Bio-Technology Research Park, Building One
800 E. Leigh Street, Suite 100
Box 980126
Richmond, VA 23298-0126

Graduate Student


Jeanne Savage


University of Missouri – Columbia, 2012, BA

Research Interests

Substance Use
Anxiety Disorders
Genetic Heterogeneity

Research Description

My research interests focus on substance use and mood/anxiety disorders, and how these two domains interact across development. I’m particularly interested in refining how these outcomes are defined in research by making use of endophenotypes, longitudinal trajectories, mixture models, and other methods that attempt to disentangle the heterogeneity inherent in such complex traits, in order to better understand the unique sets of genetic predispositions and environmental exposures that lead people from all different walks of life to develop problems with alcohol, depression, anxiety – or all of these.


Selected Publications

Simone BA; Dan T; Palagani A; Jin L; Han SY; Wright C; Savage JE; Gitman R; Lim MK; Palazzo J; Mehta MP; Simone NL, 2016. Caloric restriction coupled with radiation decreases metastatic burden in triple negative breast cancer.  Cell Cycle 15(17):2265-74

Savage JE; Sawyers C; Roberson-Nay R; Hettema JM, 2016. The genetics of anxiety-related negative valence system traits.  Am J Med Genet B Neuropsychiatr Genet.

Savage JE; Kaprio J; Korhonen T; Pulkkinen L; Rose RJ; Verhulst B; Dick DM, 2016. The effects of social anxiety on alcohol and cigarette use across adolescence: Results from a longitudinal twin study in Finland.  Psychol Addict Behav 30(4):462-74

Zhen DB; Griffith KA; Ruch JM; Camphausen K; Savage JE; Kim EJ; Sahai V; Simeone DM; Zalupski MM, 2016. A phase I trial of cabozantinib and gemcitabine in advanced pancreatic cancer.  Invest New Drugs 34(6):733-739

Carney DM; Moroney E; Machlin L; Hahn S; Savage JE; Lee M; Towbin KA; Brotman MA; Pine DS; Leibenluft E; Roberson-Nay R; Hettema JM, 2016. The Twin Study of Negative Valence Emotional Constructs.  Twin Res Hum Genet 19(5):456-64

Savage JE; McMichael O; Gorlin EI; Beadel JR; Teachman B; Vladimirov VI; Hettema JM; Roberson-Nay R, 2015. Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.  Biol Psychol 109:61-6

Savage JE; Neale Z; Cho SB; Hancock L; Kalmijn JA; Smith TL; Schuckit MA; Donovan KK; Dick DM, 2015. Level of response to alcohol as a factor for targeted prevention in college students.  Alcohol Clin Exp Res 39(11):2215-23

Savage JE; Mezuk B, 2014. Psychosocial and contextual determinants of alcohol and drug use disorders in the National Latino and Asian American Study.  Drug Alcohol Depend 139:71-8

Jin L; Lim M; Zhao S; Sano Y; Simone BA; Savage JE; Wickstrom E; Camphausen K; Pestell RG; Simone NL, 2014. The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster.  Breast Cancer Res Treat 146(1):41-50

Simone BA; Ly D; Savage JE; Hewitt SM; Dan TD; Ylaya K; Shankavaram U; Lim M; Jin L; Camphausen K; Mitchell JB; Simone NL, 2014. microRNA alterations driving acute and late stages of radiation-induced fibrosis in a murine skin model.  Int J Radiat Oncol Biol Phys 90(1):44-52

Savage JE; Slutske WS; Martin NG, 2014. Personality and gambling involvement: a person-centered approach.  Psychol Addict Behav 28(4):1198-211

Saleh AD; Simone BA; Palazzo J; Savage JE; Sano Y; Dan T; Jin L; Champ CE; Zhao S; Lim M; Sotgia F; Camphausen K; Pestell RG; Mitchell JB; Lisanti MP; Simone NL, 2013. Caloric restriction augments radiation efficacy in breast cancer.  Cell Cycle 12(12):1955-63

Ørom UA; Lim MK; Savage JE; Jin L; Saleh AD; Lisanti MP; Simone NL, 2012. MicroRNA-203 regulates caveolin-1 in breast tissue during caloric restriction.  Cell Cycle 11(7):1291-5

Saleh AD; Savage JE; Cao L; Soule BP; Ly D; DeGraff W; Harris CC; Mitchell JB; Simone NL, 2011. Cellular stress induced alterations in microRNA let-7a and let-7b expression are dependent on p53.  PLoS One 6(10):e24429

Zhang J; Schaub M; Ferdinand JA; Skelly JM; Steiner KC; Savage JE, 2010. Leaf age affects the responses of foliar injury and gas exchange to tropospheric ozone in Prunus serotina seedlings.  Environ Pollut 158(8):2627-34

Simone NL; Soule BP; Ly D; Saleh AD; Savage JE; Degraff W; Cook J; Harris CC; Gius D; Mitchell JB, 2009. Ionizing radiation-induced oxidative stress alters miRNA expression.  PLoS One 4(7):e6377

Orendovici-Best T; Skelly JM; Davis DD; Ferdinand JA; Savage JE; Stevenson RE, 2008. Ozone uptake (flux) as it relates to ozone-induced foliar symptoms of Prunus serotina and Populus maximowiziixtrichocarpa.  Environ Pollut 151(1):79-92

Schaub M; Skelly JM; Zhang JW; Ferdinand JA; Savage JE; Stevenson RE; Davis DD; Steiner KC, 2005. Physiological and foliar symptom response in the crowns of Prunus serotina, Fraxinus americana and Acer rubrum canopy trees to ambient ozone under forest conditions.  Environ Pollut 133(3):553-67

Wei C; Skelly JM; Pennypacker SP; Ferdinand JA; Savage JE; Stevenson RE; Davis DD, 2004. Responses of hybrid poplar clones and red maple seedlings to ambient O(3) under differing light within a mixed hardwood forest.  Environ Pollut 130(2):199-214

Wei C; Skelly JM; Pennypacker SP; Ferdinand JA; Savage JE; Stevenson RE; Davis DD, 2004. Influence of light fleck and low light on foliar injury and physiological responses of two hybrid poplar clones to ozone.  Environ Pollut 130(2):215-27

Shi Q; Savage JE; Hufeisen SJ; Rauser L; Grajkowska E; Ernsberger P; Wroblewski JT; Nadeau JH; Roth BL, 2003. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists.  J Pharmacol Exp Ther 305(1):131-42

Schaub M; Skelly JM; Steiner KC; Davis DD; Pennypacker SP; Zhang J; Ferdinand JA; Savage JE; Stevenson RE, 2003. Physiological and foliar injury responses of Prunus serotina, Fraxinus americana, and Acer rubrum seedlings to varying soil moisture and ozone.  Environ Pollut 124(2):307-20

Orendovici T; Skelly JM; Ferdinand JA; Savage JE; Sanz MJ; Smith GC, 2003. Response of native plants of northeastern United States and southern Spain to ozone exposures; determining exposure/response relationships.  Environ Pollut 125(1):31-40

Yuska DE; Skelly JM; Ferdinand JA; Stevenson RE; Savage JE; Mulik JD; Hines A, 2003. Use of bioindicators and passive sampling devices to evaluate ambient ozone concentrations in north central Pennsylvania.  Environ Pollut 125(1):71-80

Runyon SP; Peddi S; Savage JE; Roth BL; Glennon RA; Westkaemper RB, 2002. Geometry-affinity relationships of the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.  J Med Chem 45(8):1656-64

Runyon SP; Savage JE; Taroua M; Roth BL; Glennon RA; Westkaemper RB, 2001. Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene.  Bioorg Med Chem Lett 11(5):655-8

Huang Y; Kegeles LS; Bae S; Hwang D; Roth BL; Savage JE; Laruelle M, 2001. Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.  Bioorg Med Chem Lett 11(11):1375-7

Westkaemper RB; Runyon SP; Savage JE; Roth BL; Glennon RA, 2001. Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor.  Bioorg Med Chem Lett 11(4):563-6

Rauser L; Savage JE; Meltzer HY; Roth BL, 2001. Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.  J Pharmacol Exp Ther 299(1):83-9

Skelly JM; Ferdinand JA; Savage JE; Jagodzinski JM; Mulik JD, 2001. A 13-week comparison of passive and continuous ozone monitors at forested sites in north-central Pennsylvania.  J Air Waste Manag Assoc 51(9):1280-7

Glennon RA; Lee M; Rangisetty JB; Dukat M; Roth BL; Savage JE; McBride A; Rauser L; Hufeisen S; Lee DK, 2000. 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.  J Med Chem 43(5):1011-8

Kristiansen K; Kroeze WK; Willins DL; Gelber EI; Savage JE; Glennon RA; Roth BL, 2000. A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism.  J Pharmacol Exp Ther 293(3):735-46

Rothman RB; Baumann MH; Savage JE; Rauser L; McBride A; Hufeisen SJ; Roth BL, 2000. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.  Circulation 102(23):2836-41

Tsai Y; Dukat M; Slassi A; MacLean N; Demchyshyn L; Savage JE; Roth BL; Hufesein S; Lee M; Glennon RA, 2000. N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.  Bioorg Med Chem Lett 10(20):2295-9

Westkaemper RB; Runyon SP; Bondarev ML; Savage JE; Roth BL; Glennon RA, 1999. 9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist.  Eur J Pharmacol 380(1):R5-7

Lee JC; Skelly JM; Steiner KC; Zhang JW; Savage JE, 1999. Foliar response of black cherry (Prunus serotina) clones to ambient ozone exposure in central Pennsylvania.  Environ Pollut 105(3):325-31

Skelly JM; Savage JE; de Bauer Mde L; Alvarado D, 1997. Observations of ozone-induced foliar injury on black cherry (Prunus serotina, var. capuli) within the Desierto de Los Leones National Park, Mexico City.  Environ Pollut 95(2):155-8

Fredericksen TS; Kolb TE; Skelly JM; Steiner KC; Joyce BJ; Savage JE, 1996. Light environment alters ozone uptake per net photosynthetic rate in black cherry trees.  Tree Physiol 16(5):485-90

Skelly JM; Fredericksen TS; Savage JE; Snyder KR, 1996. Vertical gradients of ozone and carbon dioxide within a deciduous forest in Central Pennsylvania.  Environ Pollut 94(2):235-40

Fredericksen TS; Joyce BJ; Skelly JM; Steiner KC; Kolb TE; Kouterick KB; Savage JE; Snyder KR, 1995. Physiology, morphology, and ozone uptake of leaves of black cherry seedlings, saplings, and canopy trees.  Environ Pollut 89(3):273-83

Slepecky NB; Savage JE, 1994. Expression of actin isoforms in the guinea pig organ of Corti: muscle isoforms are not detected.  Hear Res 73(1):16-26

Savage JE; Theron AJ; Anderson R, 1993. Activation of neutrophil membrane-associated oxidative metabolism by ultraviolet radiation.  J Invest Dermatol 101(4):532-6

Spurlock ME; Savage JE, 1993. Effect of dietary protein and selected antioxidants on fatty liver hemorrhagic syndrome induced in Japanese quail.  Poult Sci 72(11):2095-105

Slepecky NB; Savage JE; Yoo TJ, 1992. Localization of type II, IX and V collagen in the inner ear.  Acta Otolaryngol 112(4):611-7

Slepecky NB; Savage JE; Cefaratti LK; Yoo TJ, 1992. Electron-microscopic localization of type II, IX, and V collagen in the organ of Corti of the gerbil.  Cell Tissue Res 267(3):413-8

Spurlock ME; Savage JE, 1992. Research note: antioxidant activity of Japanese quail liver cytosol in the absence and presence of reduced glutathione.  Poult Sci 71(5):928-31

Ras GJ; Anderson R; Taylor GW; Savage JE; van Niekerk E; Joone G; Koornhof HJ; Saunders J; Wilson R; Cole PJ, 1992. Clindamycin, erythromycin, and roxithromycin inhibit the proinflammatory interactions of Pseudomonas aeruginosa pigments with human neutrophils in vitro.  Antimicrob Agents Chemother 36(6):1236-40

O'Dell BL; Conley-Harrison J; Browning JD; Besch-Williford C; Hempe JM; Savage JE, 1990. Zinc deficiency and peripheral neuropathy in chicks.  Proc Soc Exp Biol Med 194(1):1-4

Ras GJ; Anderson R; Taylor GW; Savage JE; Van Niekerk E; Wilson R; Cole PJ, 1990. Proinflammatory interactions of pyocyanin and 1-hydroxyphenazine with human neutrophils in vitro.  J Infect Dis 162(1):178-85

Savage JE; O'Sullivan JF; Zeis BM; Anderson R, 1989. Investigation of the structural properties of dihydrophenazines which contribute to their pro-oxidative interactions with human phagocytes.  J Antimicrob Chemother 23(5):691-700

King LA; Tase T; Twiggs LB; Okagaki T; Savage JE; Adcock LL; Prem KA; Carson LF, 1989. Prognostic significance of the presence of human papillomavirus DNA in patients with invasive carcinoma of the cervix.  Cancer 63(5):897-900

King LA; Downey GO; Savage JE; Twiggs LB; Oakley GJ; Prem KA, 1989. Resection of the pubic bone as an adjunct to management of primary, recurrent, and metastatic pelvic malignancies.  Obstet Gynecol 73(6):1022-6

Monyak DJ; Twiggs LB; Potish RA; Adcock LL; Savage JE; Downey GO; Carson LF; Prem KA, 1988. Tolerance and preliminary results of simultaneous therapy with radiation and cisplatin for advanced cervical cancer.  NCI Monogr.

Hempe JM; Lauxen RC; Savage JE, 1988. Rapid determination of egg weight and specific gravity using a computerized data collection system.  Poult Sci 67(6):902-7

Anderson R; Beyers AD; Savage JE; Nel AE, 1988. Apparent involvement of phospholipase A2, but not protein kinase C, in the pro-oxidative interactions of clofazimine with human phagocytes.  Biochem Pharmacol 37(24):4635-41

Brooker DC; Savage JE; Twiggs LB; Adcock LL; Prem KA; Sanders CC, 1987. Infectious morbidity in gynecologic cancer.  Am J Obstet Gynecol 156(2):513-20

Twiggs LB; Potish RA; Leung BS; Carson LF; Adcock LL; Savage JE; Prem KA, 1987. Cytosolic estrogen and progesterone receptors as prognostic parameters in stage IB cervical carcinoma.  Gynecol Oncol 28(2):156-60

Wick MR; Stanley M; Cherwitz DL; Savage JE, 1986. Concomitant neuropeptide-producing endometrial carcinomas and ileal carcinoid tumors.  Am J Clin Pathol 85(4):406-10

Potish RA; Twiggs LB; Adcock LL; Prem KA; Savage JE; Leung BS, 1986. Prognostic importance of progesterone and estrogen receptors in cancer of the uterine cervix.  Cancer 58(8):1709-13

Twiggs LB; Potish RA; McIntyre S; Adcock LL; Savage JE; Prem KA, 1986. Concurrent weekly cis-platinum and radiotherapy in advanced cervical cancer: a preliminary dose escalating toxicity study.  Gynecol Oncol 24(2):143-8

Potish RA; Twiggs LB; Adcock LL; Savage JE; Prem KA; Levitt SH, 1986. Effect of cis-platinum on tolerance to radiation therapy in advanced cervical cancer.  Am J Clin Oncol 9(5):387-91

Potish RA; Twiggs LB; Adcock LL; Savage JE; Levitt SH; Prem KA, 1985. Paraaortic lymph node radiotherapy in cancer of the uterine corpus.  Obstet Gynecol 65(2):251-6

Adcock LL; Potish RA; Julian TM; Okagaki T; Prem KA; Twiggs LB; Savage JE, 1984. Carcinoma of the cervix, FIGO Stage IB: treatment failures.  Gynecol Oncol 18(2):218-25

Lifshitz S; Savage JE; Yates SJ; Buchsbaum HJ, 1982. Primary epidermoid carcinoma of the vulva.  Surg Gynecol Obstet 155(1):59-61

Savage JE; Phillips B; Lifshitz S; Petzold CR; Buchsbaum HJ; Larsen B; Galask RP, 1982. Bacteriuria in closed bladder drainage versus continuous irrigation in patients undergoing intracavitary radium for treatment of gynecologic cancer.  Gynecol Oncol 13(1):26-30

Lifshitz S; Savage JE; Taylor KA; Tewfik HH; Van Orden DE, 1982. Plasma prostaglandin levels in radiation-induced enteritis.  Int J Radiat Oncol Biol Phys 8(2):275-7

Bettger WJ; Savage JE; O'Dell BL, 1981. Extracellular zinc concentration and water metabolism in chicks.  J Nutr 111(6):1013-9

Bettger WJ; Reeves PG; Moscatelli EA; Savage JE; O'Dell BL, 1980. Interaction of zinc and polyunsaturated fatty acids in the chick.  J Nutr 110(1):50-8

Bettger WJ; Reeves PG; Savage JE; O'Dell BL, 1980. Interaction of zinc and vitamin E in the chick.  Proc Soc Exp Biol Med 163(3):432-6

Lifshitz S; Savage JE; Roberts JA, 1980. Office detection of vulvar malignancy.  J Iowa Med Soc 70(8):343-6

Savage JE, 1980. Obstetrics through the retrospectroscope.  South Med J 73(11):1516-20

Savage JE, 1979. A sketch of the history of obstetrics and gynecology in Maryland, 1770-1976.  Md State Med J 28(9):53-8

Benezet HJ; Knowles CO; Campbell JR; Savage JE, 1978. Excretion balance, metabolic fate, and tissue residues following treatment of lactating goats and laying hens with thidiazuron cotton defoliant.  J Agric Food Chem 26(3):622-7

Cherry JA; Savage JE, 1974. Comparative response of chicks and rats to dietary thyroactive and antihyrotoxic supplements.  Poult Sci 53(4):1316-24

Harris ED; Gonnerman WA; Savage JE; O'Dell BL, 1974. Connective tissue amine oxidase. II. Purification and partial characterization of lysyl oxidase from chick aorta.  Biochim Biophys Acta 341(2):332-44

Savage JE, 1972. Amino acid and mineral interrelationships.  Poult Sci 51(1):35-43

Stutz MW; Savage JE; O'Dell BL, 1972. Cation-anion balance in relation to arginine metabolism in the chick.  J Nutr 102(4):449-57

Stutz MW; Savage JE; O'Dell BL, 1972. Effect of dietary cations and arginine on lysine metabolism in the chick.  Poult Sci 51(4):1283-7

O'Dell BL; Burpo CE; Savage JE, 1972. Evaluation of zinc availability in foodstuffs of plant and animal origin.  J Nutr 102(5):653-60

Stutz MW; Savage JE; O'Dell BL, 1971. Relation of dietary cations to arginine-lysine antagonism and free amino acid patterns in chicks.  J Nutr 101(3):377-84

Stutz MW; Savage JE; O'Dell BL, 1971. Identification of -alanyl-lysine in chick muscle.  Poult Sci 50(3):887-9

Chou WS; Rucker RB; Savage JE; O'Dell BL, 1970. Impairment of collagen and elasin crosslinking by an amine oxidase inhibitor.  Proc Soc Exp Biol Med 134(4):1078-82

Chou WS; Savage JE; O'Dell BL, 1969. Role of copper in biosynthesis of intramolecular cross-links in chick tendon collagen.  J Biol Chem 244(21):5785-9

Savage JE, 1968. Trace minerals and avian reproduction.  Fed Proc 27(3):927-31

Savage JE, 1967. Iatrogenic problems of labor.  Obstet Gynecol 30(3):462-8

Savage JE; Bird DW; Reynolds G; O'Dell BL, 1966. Comparison of copper deficiency and lathyrism in turkey poults.  J Nutr 88(1):15-25

O'Dell BL; Bird DW; Ruggles DL; Savage JE, 1966. Composition of aortic tissue from copper-deficient chicks.  J Nutr 88(1):9-14

Bird DW; Savage JE; O'Dell BL, 1966. Effect of copper deficiency and inhibitors on the amine oxidase activity of chick tissues.  Proc Soc Exp Biol Med 123(1):250-4

O'Dell BL; Savage JE, 1966. Arginine-lysine antagonism in the chick and its relationship to dietary cations.  J Nutr 90(4):364-70


O'DELL BL; HARDWICK BC; REYNOLDS G; SAVAGE JE, 1961. Connective tissue defect in the chick resulting from copper deficiency.  Proc Soc Exp Biol Med 108:402-5

O'DELL BL; SAVAGE JE, 1960. Effect of phytic acid on zinc availability.  Proc Soc Exp Biol Med 103:304-6

NEWBERNE PM; SAVAGE JE; O'DELL BL, 1960. Pathology of arginine deficiency in the chick.  J Nutr 72:347-52

SAVAGE JE; O'DELL BL, 1960. Arginine requirement of the chick and the arginine-sparing value of related compounds.  J Nutr 70:129-34

NELSON AT; PHILLIPS OC; SAVAGE JE, 1959. Obstetric anesthesia care; full-time coverage in a private hospital.  Obstet Gynecol 13(4):426-32

O'DELL BL; NEWBERNE PM; SAVAGE JE, 1958. Significance of dietary zinc for the growing chicken.  J Nutr 65(4):503-18

SAVAGE JE, 1958. Forceps delivery.  Clin Obstet Gynecol 1(4):917-39

SAVAGE JE, 1957. The University of Maryland School of Medicine and College of Physicians and Surgeons, 1807-1957.  Bull Sch Med Univ Md 42(2):27-39

SAVAGE JE, 1957. Lacerations of the birth canal.  J La State Med Soc 109(5):164-72

SAVAGE JE, 1957. An account of the early history of cesarean section in the United States.  J La State Med Soc 109(7):249-53

HOGAN AG; CRAGHEAD RW; SAVAGE JE; COLE JJ; O'DELL BL, 1957. Casein as a source of protein for the chick.  J Nutr 62(1):97-106

SAVAGE JE, 1955. Operations of vaginal delivery.  Md State Med J 4(6):347-54

SAVAGE JE, 1955. Sterilization.  Med Ann Dist Columbia 24(6):294-6; passim

SAVAGE JE, 1954. Management of the fetal arms in breech extraction: a method to facilitate application of Piper forceps.  Obstet Gynecol 3(1):55-7

SAVAGE JE, 1953. Management of the third stage of labor.  South Med J 46(4):379-84

POWELL PO Jr; SAVAGE JE, 1953. Nisentil in obstetrics.  Obstet Gynecol 2(6):658-60

SAVAGE JE, 1951. Clinical and roentgen pelvimetry: a correlation.  Am J Obstet Gynecol 61(4):809-23

BAKER JT; SAVAGE JE, 1950. Extramembranous pregnancy, report of three cases.  Bull Sch Med Univ Md 35(1):24-9, illust

SAVAGE JE, 1948. Prevention of the toxemias of pregnancy.  Bull Sch Med Univ Md 33(3):63-9

JORGENSEN CL; GRAVES JH; SAVAGE JE, 1948. Saddle block anesthesia for delivery; report of 1,000 cases.  South Med J 41(9):830-4

SAVAGE JE, 1947. Treatment of placenta previa; some historical and modern aspects.  Bull Sch Med Univ Md 32(3):97-110

Publication list retrieved from NCBI using ImpactPubs