pubmedvcu

• A systematic review of digital and wearable sensor data in the ABCD study: Insights, methods, and emerging opportunities October 7, 2026
  Research into key adolescent health domains, like problematic screen-based media use, sleep health, and physical activity, are frequently limited by error-prone self-report-based measures. To improve the measurement of such behaviors, the Adolescent Brain Cognitive Development Study (ABCD), a diverse longitudinal cohort study of nearly 12,000 U.S. youth (ages 9-10 at Baseline), includes remote sensing protocols […]
  Jordan D Alexander
• Association between polygenic liability to depression and lifetime depression in at-risk adolescents October 6, 2026
  Internalising symptoms including depression, anxiety and somatic symptoms in adolescence are common. They can be transient, but they can also persist and progress to major depressive disorder (MDD) Polygenic risk scores for major depression (MD-PGS) may help identify which symptomatic adolescents are at greatest risk of later disorder. In a mega-analysis of two longitudinal population-based […]
  Enda M Byrne
• "Nothing but a pair of shorts and a lifetime of trauma": Trauma-related concerns of US foster caregivers October 2, 2026
  CONCLUSIONS: Foster caregivers have a baseline training in trauma that facilitates their ability to identify the effects of trauma on child development and functioning. However, they still feel overwhelmed providing this care and see significant gaps in training and services that warrant attention and intervention.
  Anna W Wright
• Global, Regional, and National Burden of Heart Failure, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023 September 30, 2026
  CONCLUSIONS AND RELEVANCE: Heart failure is a significant global public health burden, and the impact is likely to increase as populations age. However, most HF etiologies can be prevented by interventions that reduce exposure to modifiable risk factors, such as elevated blood pressure, excessive alcohol consumption, and tobacco use. Etiology- and location-specific estimates can provide […]
  GBD 2023 Heart Failure Collaborators
• The Changing Landscape of Genetic Risk: Age-Related Effects of Polygenic Scores for Suicidal Behaviors September 24, 2026
  Suicidal thoughts and behaviors are a persistent public health challenge. Twin studies and genome-wide association studies (GWAS) have revealed moderate genetic influences. In exploratory analyses, we evaluated whether the impact of polygenic risk scores (PRSs) for suicide ideation (SI-PRS) and attempt (SA-PRS) varied across five waves of longitudinal data from the Add Health cohort, collected […]
  Nathan Gillespie
• Genetic Risk as Statistical Topology Rather Than Biological Essence-Reply September 16, 2026
  No abstract
  Kenneth S Kendler
• Reduction in Rates of Stressful Life Events Preceding Depressive Episodes in the Course of Recurrent Major Depressive Disorder September 16, 2026
  CONCLUSIONS: Across two large cohorts collected in different cultural settings, SLE involvement preceding episodes decreased across episode order while the rate of recurrence accelerated, and within-person analyses supported stress-episode decoupling as an individual-level process. These findings provide some of the strongest evidence yet assembled that the course of recurrent MDD is consistent with the kindling […]
  Sooyeon Min
• Network analysis of the genetic relationships between twenty psychiatric and substance use disorders September 15, 2026
  We sought to clarify, using network analysis, the structure of genetic risk factors for a wide range of psychiatric and substance use disorders. Using split halves (N=1,510,974), we computed the family genetic risk scores (FGRSs) for 20 psychiatric and substance use disorders assessed in treated individuals from the entire Swedish population born between 1960 and […]
  Kenneth S Kendler
• Use of the FLARe Smartphone App in a Trauma-Exposed Sample: A Feasibility Study September 14, 2026
  Laboratory-based paradigms allow for the collection of multimodal assessments. A fear conditioning (FC) paradigm, capturing one key risk factor for posttraumatic stress disorder (PTSD) and alcohol use disorder, has been administered in a lab-based format. Recently, a smartphone-based application (app, specifically called "Fear Learning and Anxiety Response, FLARe") of this FC paradigm has been administered […]
  Kaitlin E Bountress
• Mixed Features in Recurrent Major Depressive Disorder: Prevalence, Risk Factors, and Clinical Consequences August 31, 2026
  CONCLUSIONS: Although less prevalent in this clinically ascertained sample than in Western samples, mixed features in recurrent MDD exhibit distinct clinical patterns. This finding underscores the importance of screening for mixed features, particularly when associated depressive symptoms are present, to inform early detection and treatment planning.
  C Hyung Keun Park
• Cell-type-specific eQTLs underlie the genetic architecture of complex traits August 26, 2026
  Genetic effects on complex traits primarily act by regulating gene expression; however, this process is not well understood¹. Studies of genetic effects on gene expression (expression quantitative trait loci (eQTLs)) can inform as to the gene regulatory layer between genetic variants and complex traits². However, previous studies have not effectively captured cell-type-specific eQTLs, which are […]
  Minhui Chen
• Prospective study on physical activity and Alzheimer's disease-related biomarkers August 20, 2026
  INTRODUCTION: Evidence regarding the association between physical activity (PA) and Alzheimer's disease (AD)-related biomarkers is scarce and inconsistent.
  Paula Iso-Markku
• Age at Onset and Liability to Disorder: Estimating Covariances in Censored Populations August 20, 2026
  Studies of resemblance for disorders and other traits measured at the binary (yes/no) level between relatives frequently contain individuals who are currently in the negative category but who will become positive in future. For example, a 10-year-old may develop depression in the future, but is as yet unaffected. Such censoring can substantially bias estimates of […]
  Michael C Neale
• Expectations held by foster caregivers compared to the reality of their experiences July 31, 2026
  The experiences foster caregivers have while providing care are linked to important outcomes including placement stability for the child and foster caregiver retention within the child welfare system. Understanding the expectations prospective caregivers have about fostering, and how this compares to their lived experience while fostering, is important for building realistic expectations and addressing unmet […]
  Gina J Chan
• ADHD and Student Grades in Children from the ABCD Study^®: A Twin and Siblings Study July 24, 2026
  Attention-deficit/hyperactivity disorder (ADHD) symptoms are strongly associated with lower academic performance, yet the nature of this association remains uncertain. We analyzed data from twins and siblings in the Adolescent Brain Cognitive Development (ABCD) Study^(®) to examine the relationship between ADHD symptoms and school grades using genetically informed models. ADHD symptoms were assessed via the Child […]
  Luis F S Castro-de-Araujo
• Elucidating psychosocial outcome profiles as a function of aggregate genetic risk for suicide attempt and alcohol use disorder July 10, 2026
  Genetic factors contribute to alcohol use disorder (AUD) and suicide attempt (SA) co-occurrence. Whether individuals with high genetic liability to one outcome versus the other, or to both, differ in terms of their risk for other psychosocial outcomes is unexplored. To this end, the authors conducted a cohort study of Swedish individuals born 1965-1985, with […]
  Alexis C Edwards
• Effects of family genetic risk scores and environmental factors on risk of schizophrenia and bipolar disorder July 3, 2026
  Both genetic and environmental risk factors contribute to the development of schizophrenia (SCZ) and bipolar disorder (BD), but simultaneous investigation of how these factors influence risk has not yet been comprehensively examined in a large population. Therefore, we aimed to investigate and quantify how a multi-generational index of aggregated genetic risk (family genetic risk scores, […]
  Natassia Robinson
• Predictors of Mental Healthcare Need and Utilisation Among Asian American Adolescents With Intellectual and Developmental Disabilities July 2, 2026
  CONCLUSION: Adolescents with I/DD in the United States experience racial/ethnic disparities in mental healthcare. The findings from this suggest the need to investigate further into the intersection of race/ethnicity and I/DD in mental healthcare and the creation of policies that promote equitable access to mental healthcare services for adolescents with I/DD, especially for minority individuals.
  Kayla K Van
• LT-FGRS: a unifying R-package for the estimation of family-based genetic liabilities at population-scale June 29, 2026
  Estimates of per-individual genetic liability from large-scale family data are routinely used in biomedical research to describe genetic etiology of traits and disorders, boost the power of gene-mapping studies, and improve risk predictions. Here we present LT-FGRS, an R package for handling population-scale pedigrees and implementing multiple state-of-the-field methods for estimating genetic liability from such […]
  Emil M Pedersen
• Can We Improve the Prediction of Early Onset Mania and Hypomania in the Community? June 26, 2026
  CONCLUSIONS: Improving the accurate prediction of BD onset would benefit from greater consensus regarding the operationalisation of known risk attributes and selection of analytic models that consider sample imbalances.
  Jan Scott