pubmedvcu

• 'Regarding the scientific viewpoint in psychiatry', lecture by Carl Wernicke (1880) May 19, 2022
  In 1880 Carl Wernicke gave this plenary lecture at an annual meeting of German physicians and natural scientists. He used principles from his 1874 aphasia monograph to build a neural model of mental illness. He proposed that the brain keeps a record of experiences in distinct areas of the sensory and motor cortices in the […]
  Stephan Heckers
• Reverend Dr. Lindon Eaves: A Career Remembrance May 14, 2022
  No abstract
  Michael C Neale
• Author Correction: Indirect paths from genetics to education May 9, 2022
  No abstract
  Andrew J Schork
• A serotonergic biobehavioral signature differentiates cocaine use disorder participants administered mirtazapine May 6, 2022
  Cocaine use disorder (CUD) patients display heterogenous symptoms and unforeseeable responses to available treatment approaches, highlighting the need to identify objective, accessible biobehavioral signatures to predict clinical trial success in this population. In the present experiments, we employed a task-based behavioral and pharmacogenetic-fMRI approach to address this gap. Craving, an intense desire to take cocaine, […]
  Liangsuo Ma
• Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis May 5, 2022
  We interrogate the joint genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. We identify four broad factors (neurodevelopmental, compulsive, psychotic and internalizing) that underlie genetic correlations among the disorders and test whether these factors adequately explain their genetic correlations with biobehavioral traits. We introduce stratified genomic […]
  Andrew D Grotzinger
• The Impact of Genes and Environment on Brain Ageing in Males Aged 51 to 72 Years May 2, 2022
  Magnetic resonance imaging data are being used in statistical models to predicted brain ageing (PBA) and as biomarkers for neurodegenerative diseases such as Alzheimer's Disease. Despite their increasing application, the genetic and environmental etiology of global PBA indices is unknown. Likewise, the degree to which genetic influences in PBA are longitudinally stable and how PBA […]
  Nathan A Gillespie
• Alcohol use and cognitive aging in middle-aged men: The Vietnam Era Twin Study of Aging April 25, 2022
  CONCLUSIONS: Alcohol consumption showed minimal associations with cognitive aging among middle-aged men. Stronger associations of alcohol with cognitive aging may become apparent at older ages, when cognitive abilities decline more rapidly.
  Alexis C Garduno
• Mapping genomic loci implicates genes and synaptic biology in schizophrenia April 9, 2022
  Schizophrenia has a heritability of 60-80%¹, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory […]
  Vassily Trubetskoy
• Genome-wide Association Meta-analysis of Childhood and Adolescent Internalizing Symptoms April 4, 2022
  CONCLUSION: Genetic correlations indicate that childhood and adolescent internalizing symptoms share substantial genetic vulnerabilities with adult internalizing disorders and other childhood psychiatric traits, which could partially explain both the persistence of internalizing symptoms over time and the high comorbidity among childhood psychiatric traits. Reducing phenotypic heterogeneity in childhood samples will be key in paving the […]
  Eshim S Jami
• Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach April 3, 2022
  PURPOSE: Posttraumatic Stress Disorder (PTSD) is associated with increased alcohol use and alcohol use disorder (AUD), which are all moderately heritable. Studies suggest the genetic association between PTSD and alcohol use differs from that of PTSD and AUD, but further analysis is needed.
  Kaitlin E Bountress
• The structure of the symptoms of major depression: Factor analysis of a lifetime worst episode of depressive symptoms in a large general population sample April 3, 2022
  CONCLUSIONS: Different symptom dimensions described the structure of depressive symptoms during a lifetime worst episode in a general population sample. These symptom dimensions resembled those reported in a large clinical sample of Han-Chinese women with recurrent MD, suggesting robustness of the syndrome of MD.
  Hanna M van Loo
• Indirect paths from genetics to education April 1, 2022
  No abstract
  Andrew J Schork
• A distinctive profile of family genetic risk scores in a Swedish national sample of cases of fibromyalgia, irritable bowel syndrome, and chronic fatigue syndrome compared to rheumatoid arthritis and major depression March 31, 2022
  CONCLUSION: Patients with FM have a relatively unique family genetic risk score profile with elevated genetic risk across a range of disorders that differs markedly from the profiles of a classic autoimmune disorder (RA) and internalizing disorder (MD). A similar less marked pattern of genetic risks was seen for IBS and CFS. FSD arise from […]
  Kenneth S Kendler
• Coffee and energy drink use patterns in college freshmen: associations with adverse health behaviors and risk factors March 29, 2022
  CONCLUSIONS: The response pattern was ubiquitous, with ED + Co most likely, Co intermediate, and NoCE least likely to endorse a broad range of substance use, problem alcohol behaviors, and familial risk factors. The finding that the Co group differed from both the ED + Co and NoCE groups on 8 measures and from the […]
  Dace S Svikis
• The Emergence of Psychiatry: 1650-1850 March 25, 2022
  Western psychiatry emerged as a medical specialty caring for the mentally ill over the course of the late 18th and early 19th centuries. This emergence was a contingent process, dependent on the co-occurrence of three historical developments that together shaped the young discipline. The first was the rise of the mind as an entity with […]
  Kenneth S Kendler
• Self-reported impact of developmental stuttering across the lifespan March 21, 2022
  AIM: To examine the phenomenology of stuttering across the lifespan in the largest prospective cohort to date.
  Jessica O Boyce
• Patterns and Correlates of Polysubstance Use Among Individuals With Severe Alcohol Use Disorder March 21, 2022
  CONCLUSION: Patterns of polysubstance use are differentially related to demographic and behavioral factors among individuals with severe AUD. Assessing use across multiple substances may inform the selection of targets for treatment and prevention.
  Mallory Stephenson
• Role of parental divorce and discord in the intergenerational transmission of alcohol use disorder March 20, 2022
  CONCLUSIONS: In a population-based adult twin sample, exposure to parental divorce and relationship discord appears to be important for understanding the intergenerational transmission of AUD. These effects are broadly consistent with the idea of genetic nurturance, whereby parents transmit genetic risk for alcohol use disorder to their children indirectly via heritable aspects of the home […]
  Jessica E Salvatore
• Study protocol to quantify the genetic architecture of sonographic cervical length and its relationship to spontaneous preterm birth March 18, 2022
  INTRODUCTION: A short cervix (cervical length
  Hope M Wolf
• The Genetics of Major Depression: Perspectives on the State of Research and Opportunities for Precision Medicine March 16, 2022
  Major depression (MD) is a leading cause of disability worldwide; it arises from the action and interaction between genetic and environmental factors, and is often comorbid with other psychiatric and medical conditions. To date, upwards of 100 genetic loci have been associated with MD, giving clues to biological underpinnings. Although recent progress has yielded modest […]
  Roseann E Peterson