Published Articles

pubmedvcu

• Potential Lessons for DSM From Contemporary Philosophy of Science December 8, 2021
  No abstract
  Kenneth S Kendler
• The schizophrenia concept (for schizophrenia research special issue) December 6, 2021
  No abstract
  Kenneth S Kendler
• Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors December 4, 2021
  CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.
  Niamh Mullins
• Associations Between Traumatic Stress, Brain Volumes and Post-traumatic Stress Disorder Symptoms in Children: Data from the ABCD Study December 3, 2021
  Reduced volumes in brain regions of interest (ROIs), primarily from adult samples, are associated with posttraumatic stress disorder (PTSD). We extended this work to children using data from the Adolescent Brain Cognitive Development (ABCD) Study® (N = 11,848; M(age) = 9.92). Structural equation modeling and an elastic-net (EN) machine-learning approach were used to identify potential […]
  Daniel Bustamante
• Paradoxical cognitive trajectories in men from earlier to later adulthood November 17, 2021
  Because longitudinal studies of aging typically lack cognitive data from earlier ages, it is unclear how general cognitive ability (GCA) changes throughout the life course. In 1173 Vietnam Era Twin Study of Aging (VETSA) participants, we assessed young adult GCA at average age 20 and current GCA at 3 VETSA assessments beginning at average age […]
  Graham M L Eglit
• Differential DNA Methylation and Cardiometabolic Risk in African American Mother-Adolescent Dyads November 1, 2021
  CONCLUSION: Further study of the relations among psychological and environmental stressors, indicators of cardiovascular disease, risk, and epigenetic factors will improve understanding of cardiovascular disease risk so that preventive measures can be instituted earlier and more effectively. To our knowledge this work is the first to examine DNA methylation and cardiometabolic risk outcomes in mother-adolescent […]
  Amanda Elswick Gentry
• Comparative risk of suicide by specific substance use disorders: A national cohort study October 26, 2021
  Substance use disorders (SUDs) are important risk factors for suicide, yet little is known about how suicide risks vary by specific SUDs. We examined these risks for the first time in a large general population to facilitate comparisons across SUDs. A national cohort study was conducted of all 6,947,191 adults in Sweden. SUDs (opioid, sedative/hypnotic, […]
  Casey Crump
• Passive Sensing of Preteens' Smartphone Use: An Adolescent Brain Cognitive Development (ABCD) Cohort Substudy October 18, 2021
  CONCLUSIONS: The results of passive, objective sensing suggest that children use their phones more than they self-report. Therefore, use of more robust methods for objective data collection is necessary and feasible in pediatric samples. These data may then more accurately reflect the impact of smartphone screen use on behavioral and emotional functioning. Accordingly, the ABCD […]
  Natasha E Wade
• Polygenic score for cigarette smoking is associated with ever electronic-cigarette use in a college-aged sample October 12, 2021
  CONCLUSIONS: Genetic factors associated with regular combustible cigarette use appear to be associated with ever e-cigarette use in young adults. We did not find evidence for shared genetic factors influencing heaviness of use of combustible cigarettes and current e-cigarette use frequency.
  Megan E Cooke
• The impact of sex, age at onset, recurrence, mode of ascertainment and medical complications on the family genetic risk score profiles for alcohol use disorder October 8, 2021
  CONCLUSIONS: From a genetic perspective, AUD differs substantially as a function of AAO, recurrence, mode of ascertainment and patterns of comorbidity, suggesting caution in cross-sample comparisons of AUD cohorts that differ in these features.
  Kenneth S Kendler
• Long-term associations of cigarette smoking in early mid-life with predicted brain aging from mid- to late life October 4, 2021
  CONCLUSIONS: Heavier smoking and alcohol consumption by age 40 appears to predict advanced brain aging by age 56 in men.
  Nathan Whitsel
• Is pre-college interpersonal trauma associated with cannabis use? September 29, 2021
  CONCLUSIONS: Results show that cannabis use is prevalent among college students and is associated with IPT above and beyond associations with sex, race, and other substance use.
  Terrell A Hicks
• The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study September 29, 2021
  CONCLUSIONS AND RELEVANCE: These results support caution against generalizing findings about depression risk factors across populations and highlight the need to increase the ancestral and geographic diversity of samples with consistent phenotyping.
  Olga Giannakopoulou
• Socioeconomic correlates of incident and fatal opioid overdose among Swedish people with opioid use disorder September 27, 2021
  CONCLUSION: Individuals with low education and receipt of social welfare had higher risks of incident opioid OD and individuals with criminal conviction were identified as a risk group for both incident and fatal opioid OD. Our findings should raise attention among health prevention policy makers in general, and among decision-makers within the criminal justice system […]
  Disa Dahlman
• OpenMx: A Modular Research Environment for Item Response Theory Method Development September 27, 2021
  There are many item response theory software packages designed for users. Here, the authors introduce an environment tailored to method development and simulation. Implementations of a selection of classic algorithms are available as well as some recently developed methods. Source code is developed in public repositories on GitHub; your collaboration is welcome.
  Joshua N Pritikin
• Lifestyle and the aging brain: interactive effects of modifiable lifestyle behaviors and cognitive ability in men from midlife to old age September 21, 2021
  We examined the influence of lifestyle on brain aging after nearly 30 years, and tested the hypothesis that young adult general cognitive ability (GCA) would moderate these effects. In the community-dwelling Vietnam Era Twin Study of Aging (VETSA), 431 largely non-Hispanic white men completed a test of GCA at mean age 20. We created a […]
  Carol E Franz
• Health symptoms after war zone deployment-related mild traumatic brain injury: contributions of mental disorders and lifetime brain injuries September 20, 2021
  CONCLUSIONS: After adjusting for a wide range of factors, OEF/OIF/OND deployment-related mTBI was still associated with PPCSs on average 10 years after the injury. These findings suggest that mTBI sustained during OEF/OIF/OND deployment may have enduring negative health effects. More studies are needed that prospectively and longitudinally track health and mental health outcomes after TBI.
  Scott D McDonald
• The Debate Between Two of the Founders of American Psychiatric Genetics, Aaron Rosanoff and Abraham Myerson, on Mendelian Models for Psychiatric Illness: 1911-1917 September 15, 2021
  In 1911, Aaron Rosanoff published among the first pedigree studies of psychiatric illness, and the first ever in the United States, claiming that the neuropathic constitution was transmitted in as a Mendelian recessive disorder. In 1917, Abraham Myerson harshly critiqued that study, focusing on the very wide phenotypic definition of neuropathic constitution. Here, I describe […]
  Kenneth S Kendler
• Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts September 6, 2021
  Comparing twins from same- and opposite-sex pairs can provide information on potential sex differences in a variety of outcomes, including socioeconomic-related outcomes such as educational attainment. It has been suggested that this design can be applied to examine the putative role of intrauterine exposure to testosterone for educational attainment, but the evidence is still disputed. […]
  Karri Silventoinen
• Ernst Rüdin's, 1911 vision of a Mendelian psychiatric genetics research program: His paper "Methods and goals of family research in psychiatry" August 20, 2021
  While working under Kraepelin in Munich, Ernst Rüdin, a Swiss-born Psychiatrist, at the age of 26, outlined in a 1911 98-page article, a detailed plan for a future Mendelian-informed family research program for psychiatry. Rüdin would go on to head the Department of Genealogical and Demographic Studies at Kraepelin's Research Institute which became one of […]
  Kenneth S Kendler