Course Materials: HGEN 619 [Fall 2010] | Virginia Institute for Psychiatric and Behavioral Genetics

Topics for 2010 Fall Session

Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision.

Date	Lecture Topic	Lecturer	Notes and Examples
Sep 29	Introduction to OpenMx	Theory-Model-Data OpenMx Introduction OpenMx Reference MatrixAlgebraExercises Assignment	OpenMx Reference Key R for OpenMx Reference Key First OpenMx Script Matrix Algebra Exercises Script
Oct 01	Testing Model Assumptions, Likelihood	OpenMx Scripting OpenMx Model Assumptions	Univariate Statistics Script Bivariate Statistics Script Univariate Twin Saturated -Matrix Raw Continuous Univariate Twin Saturated -Matrix Raw Binary Univariate Twin Saturated -Matrix Raw Ordinal
Oct 06	Univariate ACE Model (continuous & categorical data)	Twin Analysis	Univariate Twin ACE -Matrix Raw Continuous -Fill Univariate Twin ACE -Matrix Raw Continuous Univariate Twin ACE -Matrix Raw Binary Univariate Twin ACE -Matrix Raw Ordinal
Oct 08	Heterogeneity Testing (sex, age, environment)	Twin Analysis 102	Heterogeneity Twin Quant Diff [same sex] -Matrix Raw Continuous Heterogeneity Twin Quant/Qual Diff [SS+OS] -Matrix Raw Continuous Heterogeneity Twin Quant Diff [same sex] -Matrix Raw Binary Heterogeneity Twin Quant/Qual Diff [SS+OS] -Matrix Raw Binary
Oct 13	Modeling Means and Covariances	Twin Analysis 103	Moderated Twin ACE -Matrix Raw Continuous
Oct 15	Multivariate Genetic Analysis	Twin Analysis 104	Bivariate Twin ACE -Matrix Raw Continuous Multivariate Twin ACE -Matrix Raw Continuous usski.rec
Nov 05	SEM with Measured Genes	SEM with Measured Genes	UnivTwinACEGRawOrdEx.R selVATS.dat
Nov 17	Power	Power	norm_dist_sim.R mean_estimate_sim.R test_C_sim.R run_C_sim.R
	Helper Functions	Genetic Epidemiology Helper Functions	Gen Epi Helper Functions