Multivariate Phenotyping
| Time | Speaker | Topic | Presentation | Notes/Examples |
|---|---|---|---|---|
| 09:00 – 10:30 | Kenneth Kendler | Statistical Genetics of Substance Use | Introduction | |
| 11:00 – 12:30 | Hermine Maes / Roseann Peterson | Review Multivariate Genetic Analysis Review | OpenMx Helper Functions Causes of CoVariation |
Gen Epi Helper Functions MultiTwinRawCon.R usski.rec MultiTwinRawOrdEx.R selVATSPSUD.dat MultiTwinRawOrd.output BivCCCTwinRawOrdEx.R selVA30.dat |
| 01:30 – 02:30 | Michael Neale / Ryne Estrabrook | Genetic Factor Analysis vs Item Response Model | FactorScoreConSim.R iqnl.rec MultiTwinRawConFScore.R |
|
| 03:00 – 04:00 | Michae Neale / Shaunna Clark | Measurement Invariance/ Underreporting | Measurement Invariance | octomult_10aug2010.rdata MeasurementInvarianceExample.R |
Genes, Environment & Development
| Time | Speaker | Topic | Presentation | Notes/Examples |
|---|---|---|---|---|
| 08:00 – 09:00 | Timothy York | R Review | Functions4StatisticalAnalysis.R disease.csv |
|
| 09:00 – 10:30 | Lindon Eaves | Developmental Genetic Models | Development Change Development Change PPTX |
Generate.R |
| 11:00 – 12:30 | Nathan Gillespie | Genetic Growth Mixture Models & Time Series | Longitudinal Modeling Presentation |
LongitudinalTwinAnalysisCon.R jepq_con.dat LongitudinalTwinAnalysisOrd.R jepq_ord.txt Practical.R |
| 01:30 – 03:00 | Shaunna Clark / Ryne Estabrook | Mixture Modeling/ Multi-Level Models | Mixture & Multilevel Modeling Multilevel Modeling PPTX Programming Growth Mixture Models in OpenMx |
gmm.R |
| 03:30 – 05:00 | Daniel Dick / Timothy York | Genotype Environment Interaction & Correlation | Gene-Environment Interaction & Correlation Gene-Environment Interaction & Correlation Presentation PPT |
VCxEnvSimulated STUDENT.R GxEdata.csv |
SEM & Measured Genes
| Time | Speaker | Topic | Presentation | Notes/Examples |
|---|---|---|---|---|
| 09:00 – 10:30 | Steven Boker / Timothy Brick | Dynamical Models | Introduction to Dynamical Systems Analysis | GOLDfunctions.R 1stOrderUnivariateLDE.R 2ndOrderUnivariateLDE.R LDEUnivariateExample.dat LDE1stOrderUnivariate.csv |
| 11:00 – 12:00 | Hermine Maes | SEM with Measured Genes | SEM with Measured Genotypes | UnivTwinACEGRawOrdEx.R selVATS.dat |
| 12:00 – 12:30 | Hao Wu | Issues with Likelihood Ratio Tests | Nonstandard Likelihood Ratio Test in ACE Models | EvsACEsimulation.R CEvsACEsimulation.R |
| 01:30 – 03:00 | Amy Adkins | BLUPS: Best Linear Unbiased Prediction | BLUPs for omics | nida_maus_examp_blups.R |
| 03:30 – 05:00 | Michael Bowers | Animal Models | Addiction Animal “Models” |
Integrative Approaches
| Time | Speaker | Topic | Presentation | Notes/Examples |
|---|---|---|---|---|
| 09:00 – 09:30 | Edwin van den Oord | Statistical Molecular Genetic Approaches | Introduction to Molecular Part NIDA workshop | |
| 09:30 – 10:30 | Michael Neale / Benjamin Neale | Association & Plink | Whole genome association software tutorial Association & Plink PPT |
|
| 11:00 – 12:30 | Jozsef Bukszar | Controlling False Discoveries & Data Integration | Integrating heterogeneous genetic data sets based on rigorous mathematical foundation Controlling False Discoveries & Data Integration Presentation PPT |
|
| 01:30 – 03:00 | Joseph McClay | Behavioral Metabolomics | Behavioral Metabolomics Behavioral Metabolomics Presentation PPT |
|
| 03:30 – 05:00 | Edwin van den Oord | Pharmacogenomics & Personalized Medicine | Biomarkers and Personalized Medicine |
Next-Generation Sequencing
| Time | Speaker | Topic | Presentation | Notes/Examples |
|---|---|---|---|---|
| 09:00 – 10:00 | Gregory Buck | Introduction to Next-Generation Sequencing | Introduction to DNA Sequencing Technologies Introduction to DNA Sequencing Technologies Presentation PPT |
|
| 10:00 – 11:00 | Guimin Gao | Association Tests for Rare Variants | Association Tests for Rare Variants Using Sequence Data Association Tests for Rare Variants Presentation PPTX |
|
| 11:30 – 01:00 | Michael Neale / Benjamin Neale | Exome Sequencing & P-seq | Autism exome sequencing: design, data processing and analysis Exome Sequencing & P-seq Presentation PPTX |
|
| 02:00 – 03:00 | Karolina Aberg | Methylation | Next-generation sequencing technology to study genome wide methylation pattern | |
| 03:30 – 05:00 | Tobias Guennel / Mark Reimers | RNA-seq & Chip-seq | Data Analysis for High-Throughput Sequencing Data Analysis for High-Throughput Sequencing Presentation PPT |
NIDALab.zip RNASeqLab.pdf |
Extended Pedigree Program – Part 01
| Time | Speaker | Topic | Presentation | Notes/Examples |
|---|---|---|---|---|
| 09:00 – 10:30 | Lindon Eaves | Twin-Family and Extended Pedigrees Intro | Extended Twin-Kinship Designs Extended Twin-Kinship Designs Presentation PPTX |
Some references |
| 11:00 – 01:00 | Hermine Maes | ML Correlations in Extended Pedigrees | ML Correlations | ETC5x.R ETC10x.R ETC88x.R MZM DZM MZF DZF DZOS htusmzm.rec htusdzm.rec htusmzf.rec htusdzf.rec htusdzo.rec |
| 02:00 – 03:00 | Hermine Maes | ET Designs | ET Designs | Truett et al. 1994 Eaves et al. 1999 Maes et al. 1999 Eaves et al. 2005 Maes et al. 2006 Maes et al. 2007 Keller et al. 2009 Maes et al. 2009 |
| 03:30 – 05:00 | Hermine Maes | ET Designs Practical | ET10x.R |
Extended Pedigree Program – Part 02
| Time | Speaker | Topic | Presentation | Notes/Examples |
|---|---|---|---|---|
| 09:00 – 10:30 | Hermine Maes | Extended Pedigrees | Extended Pedigrees | ET88x2pa.R |
| 11:00 – 12:30 | Hermine Maes | Practical |
