pubmedvcu

• Genetic Risk as Statistical Topology Rather Than Biological Essence-Reply September 16, 2026
  No abstract
  Kenneth S Kendler
• Reduction in Rates of Stressful Life Events Preceding Depressive Episodes in the Course of Recurrent Major Depressive Disorder September 16, 2026
  CONCLUSIONS: Across two large cohorts collected in different cultural settings, SLE involvement preceding episodes decreased across episode order while the rate of recurrence accelerated, and within-person analyses supported stress-episode decoupling as an individual-level process. These findings provide some of the strongest evidence yet assembled that the course of recurrent MDD is consistent with the kindling […]
  Sooyeon Min
• Network analysis of the genetic relationships between twenty psychiatric and substance use disorders September 15, 2026
  We sought to clarify, using network analysis, the structure of genetic risk factors for a wide range of psychiatric and substance use disorders. Using split halves (N=1,510,974), we computed the family genetic risk scores (FGRSs) for 20 psychiatric and substance use disorders assessed in treated individuals from the entire Swedish population born between 1960 and […]
  Kenneth S Kendler
• Use of the FLARe Smartphone App in a Trauma-Exposed Sample: A Feasibility Study September 14, 2026
  Laboratory-based paradigms allow for the collection of multimodal assessments. A fear conditioning (FC) paradigm, capturing one key risk factor for posttraumatic stress disorder (PTSD) and alcohol use disorder, has been administered in a lab-based format. Recently, a smartphone-based application (app, specifically called "Fear Learning and Anxiety Response, FLARe") of this FC paradigm has been administered […]
  Kaitlin E Bountress
• Mixed Features in Recurrent Major Depressive Disorder: Prevalence, Risk Factors, and Clinical Consequences August 31, 2026
  CONCLUSIONS: Although less prevalent in this clinically ascertained sample than in Western samples, mixed features in recurrent MDD exhibit distinct clinical patterns. This finding underscores the importance of screening for mixed features, particularly when associated depressive symptoms are present, to inform early detection and treatment planning.
  C Hyung Keun Park
• Cell-type-specific eQTLs underlie the genetic architecture of complex traits August 26, 2026
  Genetic effects on complex traits primarily act by regulating gene expression; however, this process is not well understood¹. Studies of genetic effects on gene expression (expression quantitative trait loci (eQTLs)) can inform as to the gene regulatory layer between genetic variants and complex traits². However, previous studies have not effectively captured cell-type-specific eQTLs, which are […]
  Minhui Chen
• Prospective study on physical activity and Alzheimer's disease-related biomarkers August 20, 2026
  INTRODUCTION: Evidence regarding the association between physical activity (PA) and Alzheimer's disease (AD)-related biomarkers is scarce and inconsistent.
  Paula Iso-Markku
• Age at Onset and Liability to Disorder: Estimating Covariances in Censored Populations August 20, 2026
  Studies of resemblance for disorders and other traits measured at the binary (yes/no) level between relatives frequently contain individuals who are currently in the negative category but who will become positive in future. For example, a 10-year-old may develop depression in the future, but is as yet unaffected. Such censoring can substantially bias estimates of […]
  Michael C Neale
• Expectations held by foster caregivers compared to the reality of their experiences July 31, 2026
  The experiences foster caregivers have while providing care are linked to important outcomes including placement stability for the child and foster caregiver retention within the child welfare system. Understanding the expectations prospective caregivers have about fostering, and how this compares to their lived experience while fostering, is important for building realistic expectations and addressing unmet […]
  Gina J Chan
• ADHD and Student Grades in Children from the ABCD Study^®: A Twin and Siblings Study July 24, 2026
  Attention-deficit/hyperactivity disorder (ADHD) symptoms are strongly associated with lower academic performance, yet the nature of this association remains uncertain. We analyzed data from twins and siblings in the Adolescent Brain Cognitive Development (ABCD) Study^(®) to examine the relationship between ADHD symptoms and school grades using genetically informed models. ADHD symptoms were assessed via the Child […]
  Luis F S Castro-de-Araujo
• Elucidating psychosocial outcome profiles as a function of aggregate genetic risk for suicide attempt and alcohol use disorder July 10, 2026
  Genetic factors contribute to alcohol use disorder (AUD) and suicide attempt (SA) co-occurrence. Whether individuals with high genetic liability to one outcome versus the other, or to both, differ in terms of their risk for other psychosocial outcomes is unexplored. To this end, the authors conducted a cohort study of Swedish individuals born 1965-1985, with […]
  Alexis C Edwards
• Effects of family genetic risk scores and environmental factors on risk of schizophrenia and bipolar disorder July 3, 2026
  Both genetic and environmental risk factors contribute to the development of schizophrenia (SCZ) and bipolar disorder (BD), but simultaneous investigation of how these factors influence risk has not yet been comprehensively examined in a large population. Therefore, we aimed to investigate and quantify how a multi-generational index of aggregated genetic risk (family genetic risk scores, […]
  Natassia Robinson
• Predictors of Mental Healthcare Need and Utilisation Among Asian American Adolescents With Intellectual and Developmental Disabilities July 2, 2026
  CONCLUSION: Adolescents with I/DD in the United States experience racial/ethnic disparities in mental healthcare. The findings from this suggest the need to investigate further into the intersection of race/ethnicity and I/DD in mental healthcare and the creation of policies that promote equitable access to mental healthcare services for adolescents with I/DD, especially for minority individuals.
  Kayla K Van
• LT-FGRS: a unifying R-package for the estimation of family-based genetic liabilities at population-scale June 29, 2026
  Estimates of per-individual genetic liability from large-scale family data are routinely used in biomedical research to describe genetic etiology of traits and disorders, boost the power of gene-mapping studies, and improve risk predictions. Here we present LT-FGRS, an R package for handling population-scale pedigrees and implementing multiple state-of-the-field methods for estimating genetic liability from such […]
  Emil M Pedersen
• Can We Improve the Prediction of Early Onset Mania and Hypomania in the Community? June 26, 2026
  CONCLUSIONS: Improving the accurate prediction of BD onset would benefit from greater consensus regarding the operationalisation of known risk attributes and selection of analytic models that consider sample imbalances.
  Jan Scott
• Co-expression-based models improve eQTL predictions for transcriptome-wide association studies and highlight new schizophrenia-associated genes June 22, 2026
  Most genetic variants associated with complex heritability phenotypes lie in non-coding regions and are thought to influence disease risk by regulating gene expression. However, most transcriptome-wide association approaches primarily model local (cis) genetic effects, leaving much of gene regulation unexplained. Here, we show that incorporating distal (trans) regulatory effects improves the prediction of gene expression […]
  Fabiana Rossi
• High Prevalence of Suicidal Behavior in Severe Alcohol Use Disorder Linked to Specific Neurocognitive Deficits: The Cognition, Alcohol, Genes, and Environment Study June 19, 2026
  CONCLUSIONS: These preliminary findings open research avenues to study the mechanisms related to the co-occurrence of AUD and STB, with the hope of reducing STB risk in this population.
  Séverine Lannoy
• Leveraging Family Genetic Risk Scores to Understand the Etiology of Suicidal Behaviors and Their Associations With Psychiatric Disorders June 19, 2026
  CONCLUSIONS: Though psychiatric disorders were associated with increased risk of SA/SD, a substantial proportion of suicidal behaviors occurred outside the context of psychiatric disorders, urging the development of screening and prevention in non-psychiatric populations. Despite their low genetic liability for SA/SD, findings suggest that the effect of genetic risk on SA/SD risk is stronger in […]
  Séverine Lannoy
• Changes in Genetic Contributions to ASD and ADHD by Year of Diagnosis June 10, 2026
  CONCLUSIONS AND RELEVANCE: By analyzing multiple polygenic scores together with simulated expectations, this study could disambiguate among competing hypotheses about scenarios that may be associated with increased rates of ADHD and ASD diagnoses. Findings support broadening diagnostic criteria as an explanation for increasing rates, with implications for understanding changes in risk factors and clinical practice.
  Sonja LaBianca
• Suicidality phenotypes reflect both shared and distinct genetic factors June 4, 2026
  Suicidality phenotypes, including suicidal ideation (SI), non-fatal suicide attempt (SA), and suicide death (SD), are heritable and exhibit both shared and phenotype-specific genetic influences. Using genomic structural equation modelling, we estimated the shared genetic architecture across GWAS of SI (176,147 cases, 1,010,300 controls), SA (53,919 cases, 1,063,988 controls), and SD (7,584 cases, 652,070 controls) and […]
  Sarah Mc Colbert