pubmedvcu

• Childhood Trauma and APOEε4 Are Associated With Patterns of Developmental Frontal Alpha Connectivity, Posttraumatic Stress, and Alcohol-Related Outcomes November 5, 2026
  Childhood trauma affects neurodevelopment and lifelong risk for posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Changes in brain structures and function are observed in young carriers of APOEε4, the genetic factor most associated with Alzheimer's disease. Longitudinal studies of APOEε4, childhood trauma, and neural connectivity in adolescence have not been explored. We studied […]
  Zoe E Neale
• Associations Among Various Mental Health Symptoms, Trauma-Related Drinking, and Alcohol Use Disorder Symptoms: Unique, Longitudinal Effects November 3, 2026
  CONCLUSIONS: Findings suggest that females with more PTSD symptoms may be a particularly high-risk group on whom interventions not only to treat these trauma-related symptoms but also to prevent the onset of AUD via TRD ought to be focused.
  Kaitlin Bountress
• Multivariate genome-wide association study of post-traumatic stress disorder, alcohol use, and alcohol use disorders October 30, 2026
  Alcohol use disorder (AUD) commonly co-occurs with posttraumatic stress disorder (PTSD). Comorbid PTSD and AUD is associated with poorer outcomes including worse treatment prognosis and significant physical health consequences. Both PTSD and AUD are polygenic in nature and genetically overlap. Previous work showed negative or non-significant associations between PTSD and alcohol consumption but positive genetic […]
  Peter B Barr
• Polygenic dissection of suicidal thoughts and behaviours in high-risk mood-disorder cohorts October 30, 2026
  Suicidal thoughts and behaviours (STB) span ideation (SI), attempt (SA), and death (SD), yet the factors distinguishing ideation from attempt remain poorly understood. Genome-wide studies suggest shared yet partially distinct genetic liabilities. However, few analyses have tested the differential contributions of SI-, SA-, and SD-related genetic liability across STB phenotypes, particularly in high-risk mood-disorder populations. […]
  Zuriel Ceja
• Examining the multivariate genetic architectures of posttraumatic stress disorder and cardiovascular disease phenotypes October 30, 2026
  Posttraumatic stress disorder (PTSD) is associated with elevated cardiovascular disease (CVD) risk, but the extent of shared inherited liability is unclear. Large genome-wide association studies (GWAS) allow for multivariate evaluation of common genetic architecture. We analyzed European-ancestry GWAS summary statistics for PTSD (N_eff ≈ 1.22 million), CVD outcomes (CVD(outcomes); coronary artery disease, stroke, hypertension; N_eff […]
  Shannon E Cusack
• Psychiatric and substance use disorder polygenic scores are associated with the exposome in youth October 16, 2026
  Gene-environment correlations (rGE) present challenges for accurately estimating the individual and joint contributions of genetic and environmental influences on risk for psychiatric and substance use disorders. The present study examined rGE between polygenic risk scores (PGS) for psychiatric and substance use disorders and environmental exposures (i.e., exposome factors) using multi-level data spanning youth- and parent-reports, […]
  I-Tzu Hung
• A systematic review of digital and wearable sensor data in the ABCD study: Insights, methods, and emerging opportunities October 7, 2026
  Research into key adolescent health domains, like problematic screen-based media use, sleep health, and physical activity, are frequently limited by error-prone self-report-based measures. To improve the measurement of such behaviors, the Adolescent Brain Cognitive Development Study (ABCD), a diverse longitudinal cohort study of nearly 12,000 U.S. youth (ages 9-10 at Baseline), includes remote sensing protocols […]
  Jordan D Alexander
• Association between polygenic liability to depression and lifetime depression in at-risk adolescents October 6, 2026
  Internalising symptoms including depression, anxiety and somatic symptoms in adolescence are common. They can be transient, but they can also persist and progress to major depressive disorder (MDD) Polygenic risk scores for major depression (MD-PGS) may help identify which symptomatic adolescents are at greatest risk of later disorder. In a mega-analysis of two longitudinal population-based […]
  Enda M Byrne
• "Nothing but a pair of shorts and a lifetime of trauma": Trauma-related concerns of US foster caregivers October 2, 2026
  CONCLUSIONS: Foster caregivers have a baseline training in trauma that facilitates their ability to identify the effects of trauma on child development and functioning. However, they still feel overwhelmed providing this care and see significant gaps in training and services that warrant attention and intervention.
  Anna W Wright
• Global, Regional, and National Burden of Heart Failure, 1990-2023: A Systematic Analysis for the Global Burden of Disease Study 2023 September 30, 2026
  CONCLUSIONS AND RELEVANCE: Heart failure is a significant global public health burden, and the impact is likely to increase as populations age. However, most HF etiologies can be prevented by interventions that reduce exposure to modifiable risk factors, such as elevated blood pressure, excessive alcohol consumption, and tobacco use. Etiology- and location-specific estimates can provide […]
  GBD 2023 Heart Failure Collaborators
• The Changing Landscape of Genetic Risk: Age-Related Effects of Polygenic Scores for Suicidal Behaviors September 24, 2026
  Suicidal thoughts and behaviors are a persistent public health challenge. Twin studies and genome-wide association studies (GWAS) have revealed moderate genetic influences. In exploratory analyses, we evaluated whether the impact of polygenic risk scores (PRSs) for suicide ideation (SI-PRS) and attempt (SA-PRS) varied across five waves of longitudinal data from the Add Health cohort, collected […]
  Nathan Gillespie
• Unravelling the genetic basis of stuttering: GWAS meta-analysis highlights link with rare speech disorders September 24, 2026
  Developmental stuttering affects up to 11% of children, with around one-fifth developing a persistent stutter. Twin and family studies indicate a strong genetic contribution and comorbidity with other heritable traits, but the common genetic architecture of clinically ascertained stuttering, persistence and recovery remains poorly characterised. We performed a genome-wide association study (GWAS) meta-analysis of 6,096 […]
  Victoria E Jackson
• Genetic Risk as Statistical Topology Rather Than Biological Essence-Reply September 16, 2026
  No abstract
  Kenneth S Kendler
• Reduction in Rates of Stressful Life Events Preceding Depressive Episodes in the Course of Recurrent Major Depressive Disorder September 16, 2026
  CONCLUSIONS: Across two large cohorts collected in different cultural settings, SLE involvement preceding episodes decreased across episode order while the rate of recurrence accelerated, and within-person analyses supported stress-episode decoupling as an individual-level process. These findings provide some of the strongest evidence yet assembled that the course of recurrent MDD is consistent with the kindling […]
  Sooyeon Min
• Network analysis of the genetic relationships between twenty psychiatric and substance use disorders September 15, 2026
  We sought to clarify, using network analysis, the structure of genetic risk factors for a wide range of psychiatric and substance use disorders. Using split halves (N=1,510,974), we computed the family genetic risk scores (FGRSs) for 20 psychiatric and substance use disorders assessed in treated individuals from the entire Swedish population born between 1960 and […]
  Kenneth S Kendler
• Use of the FLARe Smartphone App in a Trauma-Exposed Sample: A Feasibility Study September 14, 2026
  Laboratory-based paradigms allow for the collection of multimodal assessments. A fear conditioning (FC) paradigm, capturing one key risk factor for posttraumatic stress disorder (PTSD) and alcohol use disorder, has been administered in a lab-based format. Recently, a smartphone-based application (app, specifically called "Fear Learning and Anxiety Response, FLARe") of this FC paradigm has been administered […]
  Kaitlin E Bountress
• Mixed Features in Recurrent Major Depressive Disorder: Prevalence, Risk Factors, and Clinical Consequences August 31, 2026
  CONCLUSIONS: Although less prevalent in this clinically ascertained sample than in Western samples, mixed features in recurrent MDD exhibit distinct clinical patterns. This finding underscores the importance of screening for mixed features, particularly when associated depressive symptoms are present, to inform early detection and treatment planning.
  C Hyung Keun Park
• Cell-type-specific eQTLs underlie the genetic architecture of complex traits August 26, 2026
  Genetic effects on complex traits primarily act by regulating gene expression; however, this process is not well understood¹. Studies of genetic effects on gene expression (expression quantitative trait loci (eQTLs)) can inform as to the gene regulatory layer between genetic variants and complex traits². However, previous studies have not effectively captured cell-type-specific eQTLs, which are […]
  Minhui Chen
• Prospective study on physical activity and Alzheimer's disease-related biomarkers August 20, 2026
  INTRODUCTION: Evidence regarding the association between physical activity (PA) and Alzheimer's disease (AD)-related biomarkers is scarce and inconsistent.
  Paula Iso-Markku
• Age at Onset and Liability to Disorder: Estimating Covariances in Censored Populations August 20, 2026
  Studies of resemblance for disorders and other traits measured at the binary (yes/no) level between relatives frequently contain individuals who are currently in the negative category but who will become positive in future. For example, a 10-year-old may develop depression in the future, but is as yet unaffected. Such censoring can substantially bias estimates of […]
  Michael C Neale