pubmedvcu

• Structure of the Genetic Risks for Psychiatric Disorders in Swedish Population-Based Registries May 20, 2026
  CONCLUSIONS AND RELEVANCE: Using a complete epidemiological ascertainment frame for treated psychiatric disorders in a large population sample with high-quality registries, this cohort study uncovered a structure of genetic risks that, compared to prior efforts, was similar in many ways but also had important differences.
  Kenneth S Kendler
• Evaluating GPT-4o for Automated Classification of Skin Lesions Using the HAM10000 Dataset May 15, 2026
  No abstract
  Nitin Chetla
• The typology of common psychiatric disorders as depicted by genetic maps: a study based on Swedish population-based registers May 15, 2026
  We sought to clarify the inter-relationships among a range of psychiatric and substance use disorders by employing two-dimensional genetic maps, with axes defined by family genetic risk for major depression (MD) and drug use disorder (DUD). Using comprehensive Swedish national register data, we located cases of 12 disorders within this space and examined how their […]
  Kenneth S Kendler
• A Global Prospective Harmonization Framework for Suicidality, Anhedonia, and Obsessive-Compulsive Symptoms in Psychiatric Genetic Studies: A Cross-Continental Study Within the Ancestral Population Network May 11, 2026
  This study aims to prospectively collect harmonized, quantitative, and dimensional psychiatric phenotypes (suicidality, anhedonia, and obsessive-compulsive symptoms) and information on discrimination, stigma, and unfair treatment in up to 27,500 individuals across diverse ancestries and clinical populations for genetic analysis within the NIMH Ancestral Population Network (APN). Five APN projects are participating in the current study […]
  Ana M Diaz-Zuluaga
• Predicting the geographical distribution of drug use disorder in Sweden from the geographical variation in social deprivation, genetic risk and urbanization May 11, 2026
  Drug use disorder (DUD) is distributed unevenly over geographical areas of Sweden. We explore, using geographically weighted regression, the proportion of this variation associated with community levels of genetic risk, social deprivation and urbanicity. In the 5983 Demographic Statistical areas (DeSOs) within Sweden, we predict DeSO prevalence from mean genetic risk for DUD, measured by […]
  Kenneth S Kendler
• Neuron-Enriched Extracellular Vesicle MicroRNAs Reflect Hormone-Sensitive Neural Pathway Changes from Early to Late Perimenopause May 7, 2026
  The menopausal transition represents a major neuroendocrine shift marked by declining estradiol and progesterone, rising follicle-stimulating hormone, and increased vulnerability to cognitive and affective symptoms. Despite extensive evidence of hormone-related neural changes, few biomarkers directly index hormone-sensitive neuronal adaptations in vivo. Neuron-enriched extracellular vesicles (nEVs) isolated from blood provide a minimally invasive window into central […]
  Rebekah L Frye
• Adolescent music engagement is associated with less alcohol consumption and substance experimentation 5-11 years later: A genetically informative study May 7, 2026
  CONCLUSIONS: Music engagement is associated with reduced substance use in adolescence and young adulthood, driven by protective shared environmental influences rather than direct effects. Music engagement may represent a constructive environmental outlet for youth, underscoring the importance of genetically informed research. However, the results may not generalize to more contemporary and/or diverse cohorts. (PsycInfo Database […]
  Lydia Rader
• Indirect Genetic Effects on Alcohol Use Disorder and Nicotine Dependence May 1, 2026
  Substance use disorders run in families, yet the mechanisms underlying intergenerational transmission remain unclear. We investigated indirect genetic effects, pathways through which parental genotypes influence offspring phenotypes via the family environment, for alcohol use disorder (AUD), nicotine dependence (ND), and related quantitative outcomes, and aimed to identify family environmental factors through which such effects may […]
  Mannan Luo
• Subjective Sleep Traits and Cognition Across Mid- to Late-Adulthood: A Cross-Sectional Study of Gene-Environment Interplay April 30, 2026
  Genetic susceptibility to Alzheimer's disease (ad) may influence the extent to which environmental factors shape cognition, with individuals at higher genetic risk potentially exhibiting greater sensitivity to environmental exposures. Sleep, an important factor for both cognitive function and ad risk, may further moderate genetic influences (A), including both measured (AP) and latent (AL) components, as […]
  Tina T Vo-Eckerle
• The protective effect of pregnancy on risk for suicide attempt in a Swedish national cohort April 22, 2026
  We used national Swedish registry data to investigate the nature of the association between pregnancy and decreased risk for suicide attempt (SA). Analyses included pregnant individuals aged 18-35, biological fathers, and matched controls born 1975-1995. Data were available for between 366,125 and 2,129,244 females (depending on the model) and 359,622 males. We evaluated risk for […]
  Mallory Stephenson
• Prevalence of internalizing disorders, symptoms, and traits across age using advanced nonlinear models - ERRATUM April 10, 2026
  No abstract
  Hanna M van Loo
• The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder April 10, 2026
  The inclusion of polygenic scores (PGS) from genetically correlated traits such as Major Depressive Disorder (MDD) and alcohol use disorder (AUD) may improve the prediction of these outcomes and their comorbidity. Despite the importance of this work, few studies have evaluated the efficacy of this possibility. The current study evaluates the use of MDD and […]
  Jonathan L Wells
• Treatment resistant obesity among midlife women receiving care from a specialized weight management clinic April 6, 2026
  CONCLUSIONS: More than a quarter of midlife women with obesity who receive medically specialized obesity care for one year may fail to achieve ≥5% total body weight loss and demonstrate TRO. The combination of lowering dietary carbohydrates and taking FDA approved injectable medications for weight loss in midlife women may reduce their risk of TRO. […]
  Emily C Stevens
• Antigen-specific T cell responses to SARS-CoV-2 vaccination after Hematopoietic Cell Transplant or CAR T cell Therapy April 6, 2026
  The optimal timing of SARS-CoV-2 vaccination after cellular therapies remains uncertain. In a prior prospective multicenter cohort (n=466), we found no differences in humoral or SARS-CoV-2-specific T cell receptor (TCR) responses between patients vaccinated early (
  Sigrun Einarsdottir
• Network analysis of item-level neuroticism in recurrent major depression among Korean women April 5, 2026
  CONCLUSION: Neuroticism exhibited a stable structure in both groups, but global connectivity was lower in the MDD group. "Being sensitive" emerged as the central node, suggesting its potential as a target for intervention.
  Hyeona Yu
• Racial Discrimination Predicting Sleep: Examining Social Media and Television/Digital Media use During the COVID-19 Pandemic as Moderators among College Students of Color March 30, 2026
  No abstract
  Chelsea Derlan Williams
• Association between premenstrual syndrome and postnatal depression in women with recurrent major depressive disorder March 29, 2026
  Postnatal depression (PND) represents a major mental health concern with significant implications for mothers and children. Premenstrual syndrome (PMS) has been suggested as a potential risk factor for PND, although its role among women with recurrent major depressive disorder (MDD) remains unclear. Using data from the Korean Mood Disorder Genetic Study-Depression (KOMOGEN-D), an analysis of […]
  Jeong Hun Yang
• Genetic nurture in intergenerational transmission of substance use March 27, 2026
  Substance use runs in families. Beyond genetic transmission, parental genetics can indirectly influence offspring substance use through the rearing environment, known as genetic nurture. This study utilizes transmitted and non-transmitted polygenic scores to investigate genetic nurture on tobacco, alcohol, and cannabis use in up to 15,863 adults with at least one genotyped parent from Lifelines, […]
  Mannan Luo
• Mediators of attachment, frailty, and mild cognitive impairment in older adults March 26, 2026
  CONCLUSIONS: Attachment anxiety and attachment avoidance predict frailty and cognitive function through different pathways in older adults. Viewing others as trustworthy and dependable in midlife may be protective against frailty and dementia risk in old age. Focusing on improving the quality of interpersonal relationships may thus help to reduce risk. (PsycInfo Database Record (c) 2026 […]
  Erik J Buchholz
• Advancing models of PTSD-AUD comorbidity: protocol for a multimethod framework using genetics and ecological momentary assessment March 16, 2026
  Background: Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD), which are moderately heritable, frequently co-occur and contribute to significant public health burdens, particularly among economically disadvantaged urban communities. There are noted sex differences in PTSD and AUD outcomes, with evidence suggesting women have heightened susceptibility to stress-related alcohol use. Preliminary PTSD-AUD ecological momentary assessment […]
  Elizabeth A Stinson