Course Materials: HGEN 619 [Fall 2013] | Virginia Institute for Psychiatric and Behavioral Genetics

Topics for 2013 Fall Session | Syllabi Statements

Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision PDF of Neale & Maes book.

Date	Lecture Topic	Lecturer	Notes and Examples
Aug 28	Intro	Genetic Epidemiology Biometrical Genetics Path Analysis Matrix Algebra	Matrix Algebra Script
Sep 04	Summarizing Data, Testing Model Assumptions	Summarizing Data	Univariate Twin Saturated Continuous Univariate Twin Saturated Binary Univariate Twin Saturated Ordinal
Sep 11	First Twin Model, Testing Univariate Models	First Twin Model	Univariate Twin ADE Continuous Univariate Twin ACE Binary Univariate Twin ACE Ordinal
Sep 18	Power and Simulation	Power & Simulation	Normal Distribution Simulation Test C Simulation Run C Simulation Power Approximation Mean Estimates Simulation
Sep 25	Heterogeneity Models	Gene x Sex Interaction Models	Univariate Twin Heterogeneity Continuous Univariate Twin Heterogeneity Continuous +DZO
Oct 02	Genotype x Environment Interaction Models	Gene x Environment Interaction Models Purcell 2002 Medland 2008 van der Sluis 2012	Univariate Twin Moderation Continuous
	Problem Set 1		twinAceOrd_Homework2013.R
Oct 09	Extended Pedigree Models	ExtendedTwinDesign	Twin ACE Twin Parent ACE Twin Parent ACE SH Twin Parent ACE PA chatt4tp.ord
Oct 23	Bivariate Models	Bivariate Genetic Analysis	Bivariate Twin Saturated & ACE Continuous
Oct 30	Multivariate Models	Multivariate Genetic Analysis	Multivariate Twin Saturated & ACE Continuous usski.rec
Nov 06	Developmental Models	Developmental Genetic Analysis	Developmental Twin ACE Continuous jepq.txt
Nov 13	Conditional Models	Conditional Genetic Analysis	Bivariate CCC Twin ACE Ordinal Trivariate CCC Twin ACE Ordinal Sibling Interaction Twin ACE Ordinal selVATSird.dat
Nov 20	Linkage & Association	Linkage & Association	Linkage AQE Linkage & Association AEQG lipidsIBD.dat
Nov 27	Twins + Measured Genotypes	Measured Genotypes	Twin Association Model selVATS.dat
Dec 04	Miscelaneous Topics	Heath et al 1993	Direction of Causation Model
	Helper Functions		Gen Epi Helper Functions
	Example Papers	Vink et al 2009 TRHG – Coffee Consumption Medland et al 2009 Neuropsychologia – Handedness Vinkhuyzen et al 2010 Genes, Brain & Behavior – Environmental Factors van der Aa et al 2010 Int J Peds – Exercise Vink et al 2010 Addictive Behaviors – Cannabis Smit et al 2010 TRHG – Head Size