Course Materials: HGEN 619 [Fall 2013]

Topics for 2013 Fall Session | Syllabi Statements

Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision PDF of Neale & Maes book.

Date Lecture Topic Lecturer Notes and Examples
Aug 28 Intro Genetic Epidemiology Biometrical Genetics
Path Analysis Matrix Algebra
Matrix Algebra Script
Sep 04 Summarizing Data, Testing Model Assumptions Summarizing Data Univariate Twin Saturated Continuous
Univariate Twin Saturated Binary
Univariate Twin Saturated Ordinal
Sep 11 First Twin Model, Testing Univariate Models First Twin Model Univariate Twin ADE Continuous
Univariate Twin ACE Binary
Univariate Twin ACE Ordinal
Sep 18 Power and Simulation Power & Simulation Normal Distribution Simulation
Test C Simulation
Run C Simulation
Power Approximation
Mean Estimates Simulation
Sep 25 Heterogeneity Models Gene x Sex Interaction Models Univariate Twin Heterogeneity Continuous
Univariate Twin Heterogeneity Continuous +DZO
Oct 02 Genotype x Environment Interaction Models Gene x Environment Interaction Models
Purcell 2002 Medland 2008 van der Sluis 2012
Univariate Twin Moderation Continuous
Problem Set 1 twinAceOrd_Homework2013.R
Oct 09 Extended Pedigree Models ExtendedTwinDesign Twin ACE
Twin Parent ACE
Twin Parent ACE SH
Twin Parent ACE PA
Oct 23 Bivariate Models Bivariate Genetic Analysis Bivariate Twin Saturated & ACE Continuous
Oct 30 Multivariate Models Multivariate Genetic Analysis Multivariate Twin Saturated & ACE Continuous
Nov 06 Developmental Models Developmental Genetic Analysis Developmental Twin ACE Continuous
Nov 13 Conditional Models Conditional Genetic Analysis Bivariate CCC Twin ACE Ordinal
Trivariate CCC Twin ACE Ordinal
Sibling Interaction Twin ACE Ordinal
Nov 20 Linkage & Association Linkage & Association Linkage AQE
Linkage & Association AEQG
Nov 27 Twins + Measured Genotypes Measured Genotypes Twin Association Model
Dec 04 Miscelaneous Topics Heath et al 1993 Direction of Causation Model
Helper Functions Gen Epi Helper Functions
Example Papers Vink et al 2009 TRHG – Coffee Consumption
Medland et al 2009 Neuropsychologia – Handedness
Vinkhuyzen et al 2010 Genes, Brain & Behavior – Environmental Factors
van der Aa et al 2010 Int J Peds – Exercise
Vink et al 2010 Addictive Behaviors – Cannabis
Smit et al 2010 TRHG – Head Size