Topics for 2008 Fall Session
Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision.
Classic Mx Manual: Mx: Statistical Modeling by Neale, Boker, Xie & Maes, 2006.
| Date | Lecture Topic | Lecturer | Notes and Examples |
|---|---|---|---|
| Aug 28 | Causes of variation/ Biometrical Genetics | Hermine Maes | Introduction PPT Introduction PDF |
| Sep 04 | Path analysis Matrix algebra Introduction to Mx Biometrical Genetics |
Hermine Maes | Path Analysis PPT, Path Analysis PDF Matrix Algebra PPT, Matrix Algebra PDF Mx input Mx output Intro to Mx PPT, Intro to Mx PDF Biometrical Genetics PPT, Biometrical Genetics PDF |
| Sep 12 | Summarizing data/ Univariate ACE model Fitting basic models |
Hermine Maes | Saturated example files Univariate example files |
| Introduction to SEM Maximum likelihood / Goodness-of-fit Statistics |
Michael Neale | Individual Fit Twin Analysis (Enc of Biostat) Twin Studies: Software (Enc HG) Software BG (Enc Beh Sc) Likelihood example One locus example Two locus example |
|
| Sep 18 | Univariate Genetic Analysis Fitting basic models |
Hermine Maes | Univariate Models PPT, Univariate Models PDF Univariate Data PPT Univariate example files Fill in the blanks exercise |
| Sep 25 | Univariate Genetic Analysis Fitting basic models |
Hermine Maes | Threshold Models PPT, Threshold Models PDF Categorical Data PPT, Categorical Data PDF Categorical example files Threshold Calculation |
| Oct 02 | Gene x age/sex/environment interaction Testing for heterogeneity across sex/age |
Hermine Maes | Heterogeneity PPT, Heterogeneity PDF Heterogeneity example files |
| Oct 09 | Genetic models for correlated data Phenotypic FA / Fitting bivariate models |
Nathan Gillespie | Bivariate PPT, Bivariate PDF Bivariate example files |
| Oct 16 | Independent and common pathway models Fitting multivariate models |
Hermine Maes | Multivariate PPT, Multivariate PDF Multivariate example files |
| Oct 23 | Developmental continuity and change Fitting models to longitudinal data |
Nathan Gillespie | Longitudinal PPT, Longitudinal PDF BGA2000 PPT BGA2001 PPT Developmental example files |
| Oct 30 | Issues in study design & power Power Calculations & Simulation |
Michael Neale | Power PPT, Power PDF Power example files Power: Neale ea 94 Visscher 04 Visscher 08 EEA: Derks ea 06 |
| Nov 06 | Extended Pedigrees Fitting models to extended kinships |
Hermine Maes | Extended Pedigrees PPT, Extended Pedigrees PDF Extended Pedigrees example files |
| Nov 13 | Methods for identifying QTL’s QTL analysis |
Daniel Dick | Linkage and Association Intro PPT, Linkage and Association Intro PDF |
| Nov 20 | Linkage and Association Analysis Fitting Linkage and Association Models |
Sarah Medland | Linkage & Association PPT, Linkage & Association PDF Linkage and Association example files |
| Dec 04 | Item response Theory Fitting IRT Models |
Nathan Gillespie | Item Response Theory example files |
