Topics for 2008 Fall Session

Website: OpenMx
Text: Methodology for Genetic Studies of Twins and Families by Neale & Cardon, 1992 revision.
Classic Mx Manual: Mx: Statistical Modeling by Neale, Boker, Xie & Maes, 2006.

Date Lecture Topic Lecturer Notes and Examples
Aug 28 Causes of variation/ Biometrical Genetics Hermine Maes Introduction PPT
Introduction PDF
Sep 04 Path analysis
Matrix algebra
Introduction to Mx
Biometrical Genetics
Hermine Maes Path Analysis PPT, Path Analysis PDF
Matrix Algebra PPT, Matrix Algebra PDF
Mx input
Mx output
Intro to Mx PPT, Intro to Mx PDF
Biometrical Genetics PPT, Biometrical Genetics PDF
Sep 12 Summarizing data/ Univariate ACE model
Fitting basic models
Hermine Maes Saturated example files
Univariate example files
Introduction to SEM
Maximum likelihood / Goodness-of-fit Statistics
Michael Neale Individual Fit
Twin Analysis (Enc of Biostat)
Twin Studies: Software (Enc HG)
Software BG (Enc Beh Sc)
Likelihood example
One locus example
Two locus example
Sep 18 Univariate Genetic Analysis
Fitting basic models
Hermine Maes Univariate Models PPT, Univariate Models PDF
Univariate Data PPT
Univariate example files
Fill in the blanks exercise
Sep 25 Univariate Genetic Analysis
Fitting basic models
Hermine Maes Threshold Models PPT, Threshold Models PDF
Categorical Data PPT, Categorical Data PDF
Categorical example files
Threshold Calculation
Oct 02 Gene x age/sex/environment interaction
Testing for heterogeneity across sex/age
Hermine Maes Heterogeneity PPT, Heterogeneity PDF
Heterogeneity example files
Oct 09 Genetic models for correlated data
Phenotypic FA / Fitting bivariate models
Nathan Gillespie Bivariate PPT, Bivariate PDF
Bivariate example files
Oct 16 Independent and common pathway models
Fitting multivariate models
Hermine Maes Multivariate PPT, Multivariate PDF
Multivariate example files
Oct 23 Developmental continuity and change
Fitting models to longitudinal data
Nathan Gillespie Longitudinal PPT, Longitudinal PDF
Developmental example files
Oct 30 Issues in study design & power
Power Calculations & Simulation
Michael Neale Power PPT, Power PDF
Power example files
Power: Neale ea 94
Visscher 04
Visscher 08
EEA: Derks ea 06
Nov 06 Extended Pedigrees
Fitting models to extended kinships
Hermine Maes Extended Pedigrees PPT, Extended Pedigrees PDF
Extended Pedigrees example files
Nov 13 Methods for identifying QTL’s
QTL analysis
Daniel Dick Linkage and Association Intro PPT, Linkage and Association Intro PDF
Nov 20 Linkage and Association Analysis
Fitting Linkage and Association Models
Sarah Medland Linkage & Association PPT, Linkage & Association PDF
Linkage and Association example files
Dec 04 Item response Theory
Fitting IRT Models
Nathan Gillespie Item Response Theory example files