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Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Schizophrenia (SCZ) is a severe, clinically heterogeneous psychiatric disorder with a population prevalence of ~1% [1]. Twin, family, and adoption studies consistently show a strong genetic component, with heritability estimates of around 0.75–0.80 [2,3,4,5,6], and family history (FH) remains the strongest risk factor for developing SCZ [7]. Despite high heritability, ~2/3 of SCZ cases report no FH of psychotic illness, and most subjects with a positive FH (FH+) report only a single affected relative [8, 9], concordant with the rates ...

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Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

In the last decade, genome-wide association studies (GWAS) have identified a large number of common genetic risk variants associated with complex human phenotypes (Visscher et al., 2017). Many genetic variants identified by GWAS exhibit varying degrees of genetic pleiotropy (Solovieff et al., 2013), and investigating the nature of these shared genetic risks is important for improving our understanding of the etiology and underlying genetic architecture of complex human disorders. A widely used method for assessing the genetic relationship between two ...

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