Current Grants | Virginia Institute for Psychiatric and Behavioral Genetics

id	PI Name	Grant/Project Name	NIH or non-NIH	expiry	Public Health Relevance Statement/Non-Scientific Summary
1	Amstadter (MPI) and Lott (MPI; Emory)	Integrating genetic and ecological momentary assessment technologies to advance models of PTSD-AUD comorbidity (R01 AA030549)	NIH	-0001-11-30	Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) commonly co?occur and are likely to increase in prevalence following the COVID?19 pandemic given the vast health, psychiatric, and economic toll this pandemic is causing particularly among persons of color. Understanding risk and protective factors for AUD and PTSD is critical to inform effective prevention and intervention planning; these conditions have shared latent genetic risk as well as a molecular genetic correlation, and the onset of one condition may increase risk for development of the other condition and thus multi?method studies that integrate shared genetic and phenotypic risk are needed. The present study will conduct a multi?method investigation of PTSD and AUD among a highly trauma?exposed at?risk population of inner?city residents for whom the COVID?19 pandemic may be particularly impactful for to rigorously test models of comorbidity thereby shedding light on these important public health.
2	Amstadter (MPI) and Meyers (MPI; SUNY)	Genetic relationships between PTSD and Alcohol Use Disorder: Integrating GWAS and Deeply Phenotyped Longitudinal data (R01 AA030010)	NIH	-0001-11-30	Childhood trauma exposure, particularly in the form of interpersonal violence, increases risk for alcohol use disorder (AUD), posttraumatic stress disorder (PTSD) and their co-occurrence, perhaps through complex interactions of molecular genetic risk, and trauma-related disturbances in neural development; however, knowledge is limited in this area due to limitations of prior research, including lack of longitudinal data in multiple domains and reliance on outdated genetic designs. Using cutting-edge statistical genetics techniques and results from existing
3	Amstadter (MPI) and Meyers (MPI; SUNY)	Genetic Comorbidity of PTSD and Substance Use Disorders in Diverse Populations (R01DA060596)	NIH	-0001-11-30	The overarching goal of this proposal is to understand the genetic relationships between Substance Use Disorders (SUD, i.e., alcohol, nicotine, cannabis, opioid) and Posttraumatic Stress Disorder (PTSD) while increasing representation of individuals of diverse ancestry in psychiatric genetics research. The immense framework of the Psychiatric Genomics Consortium (PGC) will be used to allow for scientific collaboration, phenotypic harmonization across thousands of participants through the PGC-PTSD and PGC-SUD workgroups, and for building upon the success of each group in ancestral diversity. This research will increase understanding of the etiology of PTSD and SUD, informing prevention and intervention efforts tailored to those with co-occurring PTSD and SUDs and moreover will increase inclusion of individuals of African and Latinx descent in large-scale genome-wide association studies.
4	Bacanu	Core 3: Bioinformatics and Analysis Core (5P50AA022537-07)	NIH	-0001-11-30	The BioInformatics and Analysis (BIA) core is responsible in helping human and animal project researchers to analyze their data and to synergistically integrate the results from all this projects.
5	Bacanu	Assessing miRNA expression in the Corticolimbic System of Major Depressive Disorder (M2102190)	NIH	-0001-11-30	We are assessing the differences in gene expression between miRNA (and their target genes) in postmortem brains of subjects with and without a diagnosis of major depressive disorder.
6	Bacanu (site PI); Hettema (Texas A&M) is PI	Genome-wide association studies of anxiety spectrum phenotypes: Furthering the PGC Anxiety Disorders Working Group (M20000751)	NIH	-0001-11-30	Anxiety disorders are quite common, chronic, and disabling. Both genetic factors and exposure to environmental stress contribute to their development. The identification of the genes that play a role in their development can provide new clues to their causes and new directions for prevention and treatment research.
7	Bountress	Alcohol Use Phenotypes and Posttraumatic Stress Disorder: Investigating Shared Genetic, Behavioral, and Psychophysiological Risk Factors (5K01AA028058-03)	NIH	-0001-11-30	Alcohol consumption (alcohol quantity x frequency/AQF), Alcohol Use Disorders (AUDs) and posttraumatic stress disorder (PTSD) often co-occur, and there is emerging evidence that shared genetic risk may partially account for the high rates of this co-occurrence. This project seeks to clarify the shared molecular genetic underpinnings of the PTSD-AQF/AUD co-occurrence, while testing two key laboratory-based phenotypes (i.e., distress tolerance and anxiety sensitivity) as potential predictors, and socioeconomic status and social support as moderators of genetic effects. This K01 award will provide the candidate with the necessary training to become an independent, federally-funded investigator in the intersection of traumatic stress-related outcomes, laboratory-based paradigms, and psychiatric and statistical genetics.
8	Brown	Depression, Stress, and Down Syndrome. A Multimethod Approach to Assessment (5K08HD092610-04)	NIH	-0001-11-30	This K08 award will provide the candidate with the training necessary to pursue a multimodal program of research, including the development of assessment tools for depression and stressful life events and the incorporation of clinical and biomarker data to better identify depression in people with Down syndrome (Ds). Given that depressive symptoms are modifiable via psychosocial or pharmacologic intervention, the development of tools to facilitate the recognition of depression in people with Ds could lead to advances in research aimed at reducing the risk (or progression) of depression in this highly vulnerable population.
9	Brown	Impact of COVID-19 on the Mental Health of People with Down Syndrome (K08HD092610-03S1)	NIH	-0001-11-30	This supplemental funding project, which is directly related to Down syndrome, will expand the scope of our research by: (1) conducting a longitudinal mental health surveillance study of the COVID-19 pandemic on caregiver stress and the mental health of their children with Down syndrome; (2) ascertaining a sample of 50 adolescents and young adults with DS reporting the highest and lowest COVID-related stress exposure to conduct a detailed psychiatric profile and buccal cell collection, and (3) assessing DNA methylation, telomere length, and micronuclei frequency in this ascertained sample to identify potential biomarkers associated with COVID-related stress. These studies could aid understanding stress-related sequalae of COVD-19 on psychiatric functioning and acquired genetic/chromosomal instability in people with Down syndrome, and lay the groundwork for efforts to prevent or ameliorate these effects.
10	PI: Brown	Development and Validation of the Down Syndrome Regression Rating Scales	NIH	-0001-11-30	Down Syndrome Regression Disorder (DSRD) is a devastating condition that is being increasingly identified and is of growing interest in the Down syndrome (DS) community. This study aims to recruit a large cohort of caregivers of adolescents and young adults with DS to develop and validate the Down Syndrome Regression Rating Scale, a novel low-burden assessment tool to aid in the screening and monitoring of DSRD.
11	Edwards	The Etiology of Risk: Alcohol and Drug Use Disorders and Suicidal Behavior (5R01AA027522-03)	NIH	-0001-11-30	This project seeks to clarify the mechanisms by which alcohol and substance use disorders are related to risk of suicidal behavior. We will apply a range of novel and sophisticated methodological approaches, using data from Swedish national registries. Given close parallels between substance misuse and suicidal behavior across Sweden and the US, these findings have the potential to identify targets for prevention and intervention.
12	Edwards	Harnessing advances in the genetics of suicidality to identify and dissect psychosocial pathways to risk (1R01MH129356-01)	NIH	-0001-11-30	The specific aims of this project will leverage recent advances in the molecular genetics of suicidality to clarify the mechanisms by which aggregate genetic liability relates to suicidal thoughts and behaviors. We will use seven independent samples to explore how genetic liability exerts its effects across the life course via behavioral mediators and in the context of environmental exposures. This integrative approach will provide critical psychosocial context to biological findings.
13	Edwards	The Etiology of Suicidal and Non-Suicidal Self-Injury in a Population-Based Sample	Non (American Foundation for Suicide Prevention)	-0001-11-30	Non-suicidal self-injury (NSSI) and suicidal behaviors are correlated but distinct outcomes, and how they are etiologically related remains unclear. This study aims to assess how a range of sociodemographic, behavioral, and environmental predictors are similarly or differentially related to NSSI and suicidal attempt in a large, population-based study, to clarify shared etiology. We will further assess the impact of aggregate genetic risk for correlated outcomes (substance misuse, major depression, personality) on these distinct outcomes.
14	Gillespie	Using transmitted and untransmitted gene networks to identify molecular pathways to substance use & misuse in genetically controlled twins (1R01DA052453-01A1)	NIH	-0001-11-30	Multiple genetic risks cause alcohol, nicotine and cannabis substance use (SU) and substance use disorders (SUDs). However, genetic studies alone cannot explain the cascade of molecular changes between SNPs and SU and SUDs. Nor can current approaches correctly measure the causal impact of genetic differences on parental and home environments linked to SU and SUDs. Molecular studies that link GWAS results to gene expression data via eQTL findings have increased our understanding of the etiology of SU and SUDs. Yet, they fail to capture complex gene interactions that are the hallmark of complex traits including SU and SUDs, or are mostly underpowered (especially from brain tissues). Another limitation is that genetic and molecular studies neglect environmental confounding. We know that parents create and influence children
15	Gillespie	Understanding the relationship between female reproductive span and dementia risk (R21 AG074212-01)	NIH	-0001-11-30	It is projected that by the year 2030 more than 60 million people worldwide will be living with Alzheimer
16	Kendler	2/4 Asian Bipolar Genetics Network (A-BIG-NET); 1R01MH130665	NIH	-0001-11-30	This proposal will leverage the Asian Bipolar Genetics Network (A?BIG?NET), an international collaboration of investigators from the U.S., Taiwan, South Korea, Singapore, India and Pakistan, to carry out a molecular genetics study of bipolar disorder in East and South Asia. It will establish a valuable genetics resource with 4x low?pass whole genome sequence and rich phenotype data that will dramatically increase the worldwide diversity of genetics data on bipolar disorder, an important step to accelerate gene discovery in this disorder and advance global mental health equity.
17	Kendler and Flint (MPI)	Improving the interpretability of genetic studies of major depressive disorder to identify risk genes; 1R01MH130581	NIH	-0001-11-30	The research proposed here will contribute to an understanding of the causes major depressive disorder, the commonest psychiatric disorder and a leading cause of disability throughout the world. The proposal will improve our ability to diagnose depression from electronic health records, generate insights into the genetic architecture of depression, separating out specific from non?specific genetic risk factors, and will identify, from the analysis of sequencing data, genes that are involved in the etiology of the disorder. The research will provide newinsights into disease, and well enable the development of more effective therapy.
18	Kendler	Social, Developmental and Epidemiology of Alcohol Use Disorders (5R01AA023534-07)	NIH	-0001-11-30	This project seeks to clarify the nature and significance of the heterogeneity of alcohol use disorder, to understand how the risk for the disorder is transmitted within couples, families, and large pedigrees, the nature and causes of alcohol related medical complications and the impact of acculturation on risk in immigrants. To meet these goals, we will apply advanced statistical methods to a unique set of epidemiological resources available in Sweden. The findings will be relevant to the US, with potential impacts on prevention, treatment and policy.
19	Kendler	Genetic, Social, and Developmental Epidemiology of Drug Use Disorders (5R01DA030005-12)	NIH	-0001-11-30	This project seeks to clarify etiologic pathways to aggregate drug abuse and opiate abuse more specifically. To accomplish this goal, we will utilize a unique and growing set of epidemiological resources available in the country of Sweden and a range of advanced statistical modeling methods. The resulting findings will be relevant to the US and other developed countries, with potential impacts on drug abuse prevention, treatment and policy.
20	Kendler	An Integrative Approach to the Etiology of Internalizing Disorders in the Lifelines Cohort (1R01MH125902-01A1)	NIH	-0001-11-30	This project seeks to clarify the etiology of key internalizing psychiatric disorders and closely associated functional medical disorders by applying a range of methods from epidemiology, genetic epidemiology and molecular genetics to the large informative population-based cohort in the Netherlands called Lifelines. We will attempt to understand the origins of the comorbidity between these disorders and how genes and environment contribute to their development. To meet these goals, we will apply advanced statistical methods to a unique set of epidemiological and molecular genetic resources.
21	Kendler	A Genome Wide Association Study of Severe Alcohol Use Disorder (5R01AA026750-04)	NIH	-0001-11-30	Alcohol Use Disorder is a heritable, common and severe substance use disorder which carries substantial medical and social morbidity. Large sample genome wide association studies (GWAS) of other complex medical and psychiatric disorders have, with sufficient sample size, led to important insights into etiology which are being translated into new treatment and preventative measures. This project will collect a large sample of severely ill cases with Alcohol Use Disorder which, together with other parallel efforts, will identify key risk genes for this disorder which can, in turn, improve our understanding of its biological causes and open up new therapeutic opportunities.
22	Kendler	Measurement of Psychopathology in large-scale genetic studies	Non-NIH (Broad)	-0001-11-30	This project was funded so that a literature review of the clinical features of Schizophrenia that index genetic risk could be conducted.
23	Kendler (site PI); Bergen (Karolinska Institute) is PI	A comparison of environmental and genetic risks for schizophrenia and bipolar disorder: A Swedish national study	NIH	-0001-11-30	This study focuses on epidemiological risk factors for Schizophrenia and Bipolar Disorder in Swedish national samples.
24	Kendler	Identifying the genetic causes of depression in a deeply phenotyped population from S. Korea	NIH	-0001-11-30	This project will collect samples from 10,000 South Korean women with recurrent major depressive disorder and 10,000 matched controls. All subjects will be genotyped and the location of genetic risk factors identified in a genome-wide association analysis. The cohort will also provide detailed information about the likely environmental causes of depression, and when combined with a similarly deeply phenotyped cohort from China, will form a uniquely powerful resource for the discovery of genes involved in recurrent major depressive disorder.
25	Lapato	Affordable Course Content Award & ACCA Sustain Grant	Non-NIH	-0001-11-30	This award supports the development of open educational resources for data science methods training. The newly created materials will be used to teach reproducible research methods and serve as the primary texts in the graduate-level data science courses HGEN611 and HGE612 at VCU.
26	Lapato	Longitudinal MicroRNA Study of Recurrent Early-Onset Major Depression	Non-NIH	-0001-11-30	The purpose of this grant is to address basic questions regarding the relationship between microRNAs (miRNAs) and the pathophysiology of major depression in adolescence. We will assess the composition and stability of miRNA expression levels in peripheral blood samples from young adults. This information will inform the design of future investigations to obtain a comprehensive map of RNA expression profiles during adolescence and provide pilot data to assess multi-omic longitudinal models of risk for depression onset that incorporate behavioral, genetic, and epigenetic variables.
27	Lapato	Genetic architecture of transdiagnostic psychosis symptom dimensions	NIH	-0001-11-30	This proposal aims to investigate the genetic architecture of psychotic symptoms as they present in schizophrenia, schizoaffective disorder, and bipolar I disorder using sophisticated statistical approaches to derive empirical phenotypes and perform genome-wide association testing in a multi-ancestry cohort. https://reporter.nih.gov/search/aqe89U-cl0KE-GSXaLMwYA/project-details/10572178.
28	Maes	Research Centre for Developmental Processes and Gradients in Mental Health - PROMENTA	Non-NIH (Research Council of Norway)	-0001-11-30	PROMENTA provides interdisciplinary and ground-breaking research elucidating the causal interplay at multiple levels including genetic risk, neurocognitive development, the proximate environment (family, friends, and neighbourhood), the sociocultural and political context, and time
29	Maes (MPI)	Using a Genetic Approach to Understand Factors Influencing Resistance to Substance Use (5R01DA054313)	NIH	-0001-11-30	This project seeks to identify factors related to high resistance to substance use. Factors increasing resistance may have the highest impact in maintaining or leading to health, as opposed to disease. Identifying these factors requires novel methods developed for this study, and developmental data
30	Neale	20/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT VCU (3U01DA051037-02S1)	NIH	-0001-11-30	Persons from marginalized communities are underrepresented in biomedical research, both as participants and as actual biomedical scientists. This under-representation results in reduced perspectives on culturally-sensitive assessments for neurobehavioral and neuroscience research, and also impoverishes public health research initiatives that may benefit health of racial minorities. To improve inclusion, the Virginia Commonwealth University (VCU) site of the Adolescent Brain Cognitive Development (ABCD) study seeks supplemental funding to enable an immersive human-subject biomedical research experience to Olive Calonge, who is graduating from Stony Brook University Spring 2021, and who has expressed an interest in developmental neuroscience.
31	Neale	Research Training: Psychiatric and Statistical Genetics (5T32MH020030-22)	NIH	-0001-11-30	There is a shortage of researchers who have skills in both statistical or molecular genetics and psychiatric epidemiology. Such individuals are needed to increase our understanding of the causes and trajectories of psychiatric disorders, so that better prevention and treatments can be developed. This training grant will educate three pre-doctoral and three postdoctoral trainees in psychiatric, behavioral, statistical and molecular genetics and neuroscience.
32	Neale	20/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT VCU (5U01DA051037-02)	NIH	-0001-11-30	The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the,scientific community to address a comprehensive range of questions concerning youth development.
33	Neale	Extensions of Mendelian Randomization Methodology for Combined Genomic and Methylomic Analysis (5R01DA049867-02)	NIH	-0001-11-30	Substance use abuse and dependence are especially complex disorders, with innumerable genetic and environmental risk factors, highly variable patterns of onset, offset and comorbidity with psychiatric disorders, cardiovascular disease and cancer. This project will develop Mendelian randomization based statistical methods and software and apply them to unique data from the Netherlands on genomic methylation. The project will improve understanding of the causes and effects of substance abuse and dependence, and how best to prevent and treat these disorders and their sequelae.
34	Neale (site PI); Klump (Michigan State) is PI	A Twin Study of Exogenous Hormone Exposure and Risk For Binge Eating	NIH	-0001-11-30	Binge eating and bulimic syndromes are significant mental health problems that disproportionately affect women. Their pronounced psychiatric and medical morbidity underscore the urgent need to understand their development. Identification of the deleterious effects of combined oral contraceptives (COCs) on binge eating could substantially reduce the risk of bulimic syndromes in vulnerable women and spearhead a much more personalized medicine approach to COC use and prescriptions.
35	Neale (site PI); Williams, Franz, & Lyons (USCD) are PIs	The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)	NIH	-0001-11-30	Alzheimer's disease is considered the most costly and burdensome disease in the U.S, and its public health impact will only grow with the increase of 65-75 year olds in the next decade. Paralleling cardiovascular disease and cancer, it is now widely recognized that a key to slowing disease progression is early identification during pre dementia phases. With cognitive and biomarker data beginning when participants were in their 50s, the longitudinal VETSA project stands to advance progress toward early identification, which may, in turn, improve quality of life and reduce societal burden.
36	Nguyen	Understanding the genomic basis of problematic alcohol use through integrative analysis of multi-omics data (1K25AA030072-01)	NIH	-0001-11-30	Alcohol use disorder (AUD) affects millions of people in the US. Although genetic studies have identified loci associated with AUD, its genetic etiology has not been fully explained. This project aims to 1) develop integrative methods for analyzing large-scale genomic datasets of AUD to increase power for genetic discovery, and 2) elucidate the genomic architecture of AUD by using systems biology approaches.
37	Riley/Nguyen (MPIs)	Establishing and Testing Ethanol Exposure Protocols in Cell Culture for iPSC Model Studies of AUD Associated Genes and Variants	Non-NIH (VCU ARC pilot grant)	-0001-11-30	None
38	Riley	Whole Genome Sequencing in Irish Multiplex Schizophrenia Families (5R01MH114593-05)	NIH	-0001-11-30	Rare sequence variation has been implicated in many human complex traits, including schizophrenia, and has been studied in unrelated cases and controls and parent:offspring trios, but remains unstudied in multiplex families. Sequencing the genomes of such families will allow comprehensive identification of variation in protein coding genes, non-coding expressed loci, regulatory sequences, and evolutionarily conserved regions, as well as detection of structural variation, and testing these alleles in a large case/control series of the same ethnic and geographic origin offers significant advantages over prior study designs, and has the potential to identify individual alleles, variant enriched genes, variant enriched non-genic sequences, and/or variant enriched genesets contributing to SCH risk in the Irish population. Such variants offer great potential for understanding the functional impact of risk alleles and improving mechanistic understanding of schizophrenia and related disorders.
39	Miles/Riley (MPI)	Cross-species Interdisciplinary Training in Alcohol Research (T32AA029975)	NIH	-0001-11-30	Project Narrative There is a shortage of researchers with the high levels of interdisciplinary skills needed to make progress in understanding the etiology and improving clinical treatment of alcohol use disorder (AUD), a major public health problem. The objective of this training grant is to educate the next generation of researchers focused on i) elucidating the risk factors for and outcomes of problem alcohol use, ii) understanding the behavioral and molecular causes and consequences of problem alcohol use, and iii) contributing to the translation of these basic findings into improvements in both treatment and prevention of AUD. The training in this program aims to educate an interdisciplinary diverse work force of researchers with a solid knowledge of multiple relevant areas, including genetics, behavior, neurobiology, data science and clinical treatment who will be prepared to have an impact on the health of millions of individuals affected by AUD.
40	Roberson-Nay	Quantification and Characterization of Bulk and L1CAM-Enriched Exosomal MicroRNA Cargo in Healthy Young People (1R21MH128562)	NIH	-0001-11-30	Early onset major depressive disorder (MD) is a prevalent and significant public health problem associated with negative immediate and long-term effects. Dysregulation of microRNAs (miRNA) has been linked to a number of disease states including MD. We propose to examine miRNAs from extracellular vesicles (ECV) in an extant, deeply phenotyped twin sample (n=284; 15-22 years; ~65% female; R01MH101518) to address critical basic science questions about the nature of ECV miRNAs during early life and their relationship to the leading cause of psychiatric impairment in young adults.
41	Roberson-Nay	Characterizing the Relationship Between Alcohol Consumption and Neuron-Derived Exosomal MicroRNA Cargo in an Adolescent-Young Adult Twin Cohort (1R21AA029492)	NIH	-0001-11-30	Early life alcohol use is a prevalent and significant public health problem associated with negative immediate and long-term effects. Perturbations of microRNAs (miRNA) has been linked to a number of disease states in animal models and human studies, including chronic alcohol use. In this application we propose to investigate bulk ECV- miRNAs as well as ECV-miRNAs released from neuronal tissues in an extant, deeply phenotyped subsample (n=313; 15-22 years; 52% female) who participated in a parent R01 study (MH101518) to address critical basic science questions about the nature of ECV miRNAs signatures associated with early life alcohol use.
42	Sheerin	Functional relations between alcohol use and mental/physical health in the wake of the COVID-19 pandemic (K01AA025692-04S1)	NIH	-0001-11-30	Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) commonly co-occur, and some of the genetic risk for these conditions is shared. This project aims to elucidate the shared molecular genetic risk and examine potential learning-based mechanisms common to both disorders, by linking large-scale genome-wide data with a clinical laboratory study. This K01 award will provide the candidate with the training necessary to pursue a multimodal program of research that aims to synthesize genetically informed research with laboratory studies of mechanism to inform upon the shared underpinnings of AUD and PTSD and advance work aimed at improving prevention and treatment efforts.
43	Sheerin	Overlap in genetic and learning-based mechanisms for alcohol use disorder and posttraumatic stress disorder (K01AA025692-04)	NIH	-0001-11-30	Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) commonly co-occur, and some of the genetic risk for these conditions is shared. This project aims to elucidate the shared molecular genetic risk and examine potential learning-based mechanisms common to both disorders, by linking large-scale genome-wide data with a clinical laboratory study. This K01 award will provide the candidate with the training necessary to pursue a multimodal program of research that aims to synthesize genetically informed research with laboratory studies of mechanism to inform upon the shared underpinnings of AUD and PTSD and advance work aimed at improving prevention and treatment efforts.
44	Sheerin	Synthesizing Aggregate Genetic and Laboratory Data to Inform Upon Risk Underlying AUD and PTSD Comorbidity	Non-NIH (VCU QUEST)	-0001-11-30	The goal of the proposed pilot study is to aggregate and harmonize two existing, genetically informed datasets from deeply phenotyped laboratory studies of fear conditioning in trauma-exposed populations. This study will also leverage large-scale genome-wide association study (GWAS) summary statistics of PTSD and problematic alcohol use. Understanding how aggregate genetic risk influences laboratory intermediate phenotypes and AUD-PTSD risk has implications for understanding etiology, informing risk prediction, and supporting down-stream targeted prevention and intervention efforts.
45	York	Genetic architecture of cervical length related to progesterone treatment and the risk of spontaneous preterm birth	NIH	-0001-11-30	The objective of this project is to establish the genetic architecture associated with cervical shortening leading to spontaneous preterm birth, and use this information to define genetic factors affecting progesterone responsiveness.