pubmedvcu

• Prevalence of internalizing disorders, symptoms, and traits across age using advanced nonlinear models - ERRATUM April 10, 2026
  No abstract
  Hanna M van Loo
• The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder April 10, 2026
  The inclusion of polygenic scores (PGS) from genetically correlated traits such as Major Depressive Disorder (MDD) and alcohol use disorder (AUD) may improve the prediction of these outcomes and their comorbidity. Despite the importance of this work, few studies have evaluated the efficacy of this possibility. The current study evaluates the use of MDD and […]
  Jonathan L Wells
• Treatment resistant obesity among midlife women receiving care from a specialized weight management clinic April 6, 2026
  CONCLUSIONS: More than a quarter of midlife women with obesity who receive medically specialized obesity care for one year may fail to achieve ≥5% total body weight loss and demonstrate TRO. The combination of lowering dietary carbohydrates and taking FDA approved injectable medications for weight loss in midlife women may reduce their risk of TRO. […]
  Emily C Stevens
• Antigen-specific T cell responses to SARS-CoV-2 vaccination after Hematopoietic Cell Transplant or CAR T cell Therapy April 6, 2026
  The optimal timing of SARS-CoV-2 vaccination after cellular therapies remains uncertain. In a prior prospective multicenter cohort (n=466), we found no differences in humoral or SARS-CoV-2-specific T cell receptor (TCR) responses between patients vaccinated early (
  Sigrun Einarsdottir
• Network analysis of item-level neuroticism in recurrent major depression among Korean women April 5, 2026
  CONCLUSION: Neuroticism exhibited a stable structure in both groups, but global connectivity was lower in the MDD group. "Being sensitive" emerged as the central node, suggesting its potential as a target for intervention.
  Hyeona Yu
• Racial Discrimination Predicting Sleep: Examining Social Media and Television/Digital Media use During the COVID-19 Pandemic as Moderators among College Students of Color March 30, 2026
  No abstract
  Chelsea Derlan Williams
• Association between premenstrual syndrome and postnatal depression in women with recurrent major depressive disorder March 29, 2026
  Postnatal depression (PND) represents a major mental health concern with significant implications for mothers and children. Premenstrual syndrome (PMS) has been suggested as a potential risk factor for PND, although its role among women with recurrent major depressive disorder (MDD) remains unclear. Using data from the Korean Mood Disorder Genetic Study-Depression (KOMOGEN-D), an analysis of […]
  Jeong Hun Yang
• Genetic nurture in intergenerational transmission of substance use March 27, 2026
  Substance use runs in families. Beyond genetic transmission, parental genetics can indirectly influence offspring substance use through the rearing environment, known as genetic nurture. This study utilizes transmitted and non-transmitted polygenic scores to investigate genetic nurture on tobacco, alcohol, and cannabis use in up to 15,863 adults with at least one genotyped parent from Lifelines, […]
  Mannan Luo
• Mediators of attachment, frailty, and mild cognitive impairment in older adults March 26, 2026
  CONCLUSIONS: Attachment anxiety and attachment avoidance predict frailty and cognitive function through different pathways in older adults. Viewing others as trustworthy and dependable in midlife may be protective against frailty and dementia risk in old age. Focusing on improving the quality of interpersonal relationships may thus help to reduce risk. (PsycInfo Database Record (c) 2026 […]
  Erik J Buchholz
• Advancing models of PTSD-AUD comorbidity: protocol for a multimethod framework using genetics and ecological momentary assessment March 16, 2026
  Background: Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD), which are moderately heritable, frequently co-occur and contribute to significant public health burdens, particularly among economically disadvantaged urban communities. There are noted sex differences in PTSD and AUD outcomes, with evidence suggesting women have heightened susceptibility to stress-related alcohol use. Preliminary PTSD-AUD ecological momentary assessment […]
  Elizabeth A Stinson
• Familial genetic risk for posttraumatic stress disorder: Associations with clinical features March 13, 2026
  In the present study, the novel family genetic risk score (FGRS) method, a reliable quantification of latent genetic risk, was applied to posttraumatic stress disorder (PTSD) to examine associations between genetic liability and clinical features of PTSD among 3,097,180 individuals in the Swedish national registries. FGRS was calculated based on lifetime PTSD status for first- […]
  Ananda B Amstadter
• Genetic influences on suicide attempt in adolescence: Evaluating mediation by impulsivity and painful and provocative events March 12, 2026
  CONCLUSIONS: Impulsivity and PPEs each contribute to risk for SA. However, there is little support for the hypothesis that genetic influences on SA are mediated by impulsivity and PPE exposure in early adolescence.
  Mallory Stephenson
• Participant ascertainment is differentially related to phenotypic characteristics and alcohol-related genetic liability in a sample with severe alcohol use disorder March 9, 2026
  CONCLUSIONS: Individuals with severe AUD exhibit heterogeneity across many risk domains, particularly for alcohol-related measures. This heterogeneity can be captured through the ascertainment of study participants via diverse modalities, improving representativeness and potentially facilitating gene identification efforts.
  Alexis C Edwards
• Genomic Study of Resilience to Posttraumatic Stress Disorder in the Million Veteran Program February 28, 2026
  CONCLUSIONS: These findings extend the literature regarding DBPR as a resilience measure and help inform our understanding of the underlying biological mechanisms.
  Cassie Overstreet
• Age effect explorer: a Shiny application to browse and visualize tissue-specific age-related gene expression changes February 12, 2026
  MOTIVATION: Understanding age-related transcriptional changes in human tissues is crucial for elucidating molecular mechanisms of aging and disease. Current genomic analysis tools often require programming expertise, limiting accessibility for comprehensive aging studies. Here, we present Age Effect Explorer, an interactive R Shiny application for systematically analyzing age- and sex-related gene expression pattern changes across 54 […]
  Menghui Chen
• Suicide risks associated with cardiovascular disease in persons with alcohol use disorder February 8, 2026
  CONCLUSIONS: In this large national cohort with AUD, CVD was associated with a ∼40 % higher risk of suicide death. Clinical care for persons with AUD should integrate mental health and prevention and treatment of CVD comorbidities to support their long-term health and survival.
  Casey Crump
• The impact of alcohol use disorder and PTSD comorbidity on risk of suicide attempt February 6, 2026
  CONCLUSIONS: PTSD and AUD are independently associated with SA, but risk is substantially exacerbated among comorbid individuals. While the total effect of these conditions on SA risk is overall comparable across sexes, females whose PTSD precedes AUD are particularly burdened by comorbidity.
  Alexis C Edwards
• Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling February 3, 2026
  The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder and phobias) are highly prevalent, often onset early and cause substantial global disability. Although distinct in their clinical presentations, they probably represent differential expressions of a dysregulated threat-response system. Here, we present a genome-wide association meta-analysis comprising 122,341 European ancestry ANX cases and 729,881 […]
  Nora I Strom
• Characterizing the co-occurrence of alcohol experimentation and suicidal thoughts and behaviors in early adolescence January 29, 2026
  This study aims to investigate the roles of decision-making processes and genetics in the co-occurrence of alcohol use and suicidal thoughts/behaviors (STB) in adolescence. We used data from the ABCD^(®) study (abcdstudy.org) and included behavioral (computerized tasks, self-report questionnaires) and genetic (polygenic scores [PGS]) measures related to cognitive (executive functions) and affective (delay-discounting, risk-taking, impulsivity) […]
  Séverine Lannoy
• Stability of Music Engagement Across Childhood, Adolescence, and Established Adulthood: A Longitudinal Twin and Adoption Study January 6, 2026
  Music engagement traits are linked to important developmental language, cognitive, and mental health outcomes, but longitudinal studies have not examined the developmental stability of music engagement across the first few decades of life, especially using genetically informative designs. The current study examined music engagement-defined as being interested and skilled at musical instruments and taking music […]
  Daniel E Gustavson