Publications authored by the Virginia Institute for Psychiatric and Behavioral Genetics are listed below. This is a partial listing pulled from PubMed.gov and contains only a sample of published articles. To see a complete list of all publications by VIPBG, use alt + click on the pubmedvcu link below.
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- Deep Phenotyping at Scale: Study Protocol for the Korean Mood Disorder Genetic Study-Depression (KOMOGEN-D) August 25, 2025A core challenge in the genetic analysis of major depressive disorder (MDD) is how to recruit large numbers of stringently diagnosed cases with sufficient information to explore the interplay between genetic and environmental risk factors and evaluate genetic influences on putative MD subtypes and key clinical features. Currently, most genome-wide association studies of MDD rely […]Sooyeon Min
- Phenome-wide association study of male and female sex chromosome trisomies in 1.5 million participants of MVP, FinnGen, and UK Biobank August 21, 2025Sex chromosome trisomies (SCTs) are the most common whole-chromosome aneuploidy in humans. Yet, our understanding of the prevalence and associated health outcomes is largely driven by observational studies of clinically diagnosed individuals, resulting in a disproportionate focus on 47,XXY and associated hypogonadism. We analyzed microarray intensity data of sex chromosomes for 1.5 million individuals enrolled […]Shanlee M Davis
- Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits August 20, 2025CONCLUSIONS: Our results suggest that combining the wide availability of diagnostic EHR data with nuanced criterion-level analyses of DSM tobacco use disorder may produce new insights into the genetics of this disorder.Emma C Johnson
- The outcome of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity August 14, 2025CONCLUSIONS: Despite important differences between our primary disorders, social and psychiatric outcomes are often robust indices of genetic risk and can reflect the levels of genetic heterogeneity.Kenneth S Kendler
- The Impact of the Parental Patterns of Morbidity and Comorbidity in the Cross-Generational Transmission of Risk for Major Depression and Alcohol Use Disorder August 14, 2025To further understand the inter-relationship of the familial transmission of major depression (MD) and alcohol use disorder (AUD), we examine, via a multivariable Cox proportional hazards model, risks for AUD and MD in 1,244,516 individuals born in Sweden from 1970 to 1990 to intact mother-father pairs as a function of parental diagnoses of MD and/or […]Kenneth S Kendler
- Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects August 12, 2025Psychiatric conditions share common genes, but mechanisms that differentiate diagnoses remain unclear. We present a multidimensional framework for functional analysis of rare copy number variants (CNVs) across 6 diagnostic categories, including schizophrenia (SCZ), autism (ASD), bipolar disorder (BD), depression (MDD), PTSD, and ADHD (N = 574,965). Using gene-set burden analysis (GSBA), we tested duplication (DUP) […]Worrawat Engchuan
- Genetic risk effects on psychiatric disorders act in sets August 8, 2025Genetic studies of psychiatric disorders have typically assumed that all genetic effects contribute additively to disease liability. However, it is likely that psychiatric disorders have unrecognized subtypes, where synergistic sets of risk variants co-occur within certain cases more than expected under additivity. The existence of synergistic sets induces a structured form of statistical interactions called […]Jolien Rietkerk
- A Call for Inclusion: Children With Intellectual Disabilities in Trauma Treatment Research August 7, 2025CONCLUSIONS: The evidence base for the ISTSS clinical care guidelines of child PTSD treatment is not representative of children with ID. Improved documentation of inclusion/exclusion criteria, reporting of disability as a demographic characteristic, and inclusion of children with ID in PTSD treatment trials are needed to improve representation of children with ID in PTSD research.Zackary F Moore
- The Genetics of Cerebellar Structure and Associations With Cognitive Performance: A Twin Magnetic Resonance Imaging Study August 6, 2025The cerebellum, traditionally associated with motor control, is increasingly recognized for its involvement in higher-order cognitive functions. However, the role of cerebellar subregions in cognition remains underexplored, as are the roles of genetic factors on cerebellar structure and brain-behavioral associations. The primary goal of this study was to investigate the relationship between cerebellar subregion volumes […]Gretchen Lutz
- Longitudinal predictors of alcohol use and problems during the COVID-19 pandemic in an at-risk veteran sample August 4, 2025Background: Individuals with pre-existing heavy alcohol use, prior traumatic exposures, and psychiatric disorders were considered an at-risk group for increased alcohol use and problems in the context of the COVID-19 pandemic.Objective: This study recruited from a multi-centre longitudinal cohort study of US military service members/veterans with combat exposure to examine the trajectories of alcohol use […]Angela J Zaur
- Identifying different phenotypes in acute fulminant myocarditis patients treated with venoarterial extracorporeal membrane oxygenation by latent class analysis August 2, 2025CONCLUSIONS: Using LCA, we identified three clinical phenotypes of AFM patients treated with VA-ECMO. These may reflect different pathophysiological processes in this patient population. Our findings may help identify treatment targets and select patients for future clinical trials.Haiming Niu
- Proportional Sedation for Persistent Agitated Delirium in Palliative Care: A Randomized Clinical Trial July 31, 2025CONCLUSIONS AND RELEVANCE: The results of this randomized clinical trial indicate that proactive use of scheduled sedatives, particularly lorazepam-based regimens, may reduce persistent restlessness and/or agitation in patients with advanced cancer and delirium in the palliative care setting.David Hui
- Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents July 25, 2025Substance use has been associated with differences in adult brain morphology; however, it is unclear whether these differences precede or are a result of substance use substance use. We investigated the impact of polygenic risk scores (PRSs) for cannabis use disorder (CUD) and general substance use and substance use disorder liability (SU/SUD) on brain morphology […]Sydney Kramer
- Profiles of Genetic Risks for Psychotic Disorders July 9, 2025CONCLUSIONS AND RELEVANCE: In a Swedish population, none of the 4 disorders appeared, from a genetic perspective, to be subtypes of SZ, BD, or MD. Further genetics research on the syndromes of DD, AP, PNOS, and SAD have much to teach about the relationship between dimensions of genetic risks and the clinical presentation and course […]Kenneth S Kendler
- Agonist- and stress-driven compartmentalized phosphoinositide signaling in cells July 6, 2025Phosphoinositides (PIPs) are essential lipid messengers that regulate cellular responses to external stimuli and stress through spatially organized signaling pathways. In recent years, compartment-specific mechanisms by which PIP signaling integrates diverse cellular processes have been extensively expanded. This review discusses the distinct roles of PIP signaling across cellular compartments, including the plasma membrane, endosomes, lysosomes, […]Mo Chen
- The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders June 26, 2025Psychiatric disorders display high levels of comorbidity and genetic overlap^(1,2). Genomic methods have shown that even for schizophrenia and bipolar disorder, two disorders long-thought to be etiologically distinct³, the majority of genetic signal is shared⁴. Furthermore, recent cross-disorder analyses have uncovered over a hundred pleiotropic loci shared across eight disorders⁵. However, the full scope of […]Andrew D Grotzinger
- Evaluation of a 20-Item Version of the Trauma-Related Drinking to Cope Questionnaire June 26, 2025CONCLUSION: These findings highlight the TRD-20 as a useful measure for determining an individual's PTSD-specific drinking motives, which carries implications for improving understanding and treatment of PTSD-AUD comorbidity.Sage E Hawn
- The Mediating Role of Social and Environmental Determinants of Health in the Association Between Race and Preterm Birth Risk June 16, 2025Objective: To evaluate the mediating role of social and environmental determinants of health (SEDH) in the relationship between self-identified race and preterm birth risk. Methods: Data on birth outcomes and five broad domains of SEDH were obtained from the Pregnancy, Race, Environment, Genes study, a prospective cohort of pregnant women (50% Black American) in Richmond, […]Julia J Brittain
- AAVone: A cost-effective, single-plasmid solution for efficient AAV production with reduced DNA impurities June 12, 2025Currently, the most common approach for manufacturing good manufacturing practice (GMP)-grade adeno-associated virus (AAV) vectors involves transiently transfecting mammalian cells with three plasmids that carry the essential components for production. Here, we developed an all-in-one, single-plasmid AAV production system, called AAVone, in which the adenovirus helper genes (E2A, E4orf6, and VA RNA), AAV packaging genes […]Rongze Yang
- Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins June 9, 2025The amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal hypotheses regarding the direction of causation between Aβ40 and Aβ42 and total Tau (t-Tau) plasma biomarkers. Plasma Aβ40, Aβ42, t-Tau, and neurofilament light chain (NFL) were measured in 1,035 men (mean = 67.0 years) using Simoa […]Nathan A Gillespie