Publications authored by the Virginia Institute for Psychiatric and Behavioral Genetics are listed below. This is a partial listing pulled from PubMed.gov and contains only a sample of published articles. To see a complete list of all publications by VIPBG, use alt + click on the pubmedvcu link below.
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- Internalizing Psychiatric Symptoms in People With Mosaicism for Trisomy 21 January 17, 2025People with mosaicism for trisomy 21 have been shown to exhibit many of the same phenotypic traits present in people with non-mosaic Down syndrome, but with varying symptom severity. However, the behavioral phenotype of people with mosaic Down syndrome (mDS) has not been well characterized. This study aimed to examine the prevalence of self-report and […]Ruth C Brown
- Unidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation January 9, 2025Cigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which may underpin some of the adverse health sequelae of smoking. However, prior causal analyses with Mendelian Randomisation (MR) have found limited support for such effects. […]Madhurbain Singh
- Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study December 31, 2024Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in […]Yazheng Di
- Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research December 28, 2024Psychiatric disorders are highly comorbid, heritable, and genetically correlated [1-4]. The primary objective of cross-disorder psychiatric genetics research is to identify and characterize both the shared genetic factors that contribute to convergent disease etiologies and the unique genetic factors that distinguish between disorders [4, 5]. This information can illuminate the biological mechanisms underlying comorbid presentations […]Na Cai
- The Mechanisms Underlying the Intergenerational Transmission of Substance Use and Misuse: An Integrated Research Approach December 23, 2024Substance use and substance use disorders run in families. While it has long been recognized that the etiology of substance use behaviors and disorders involves a combination of genetic and environmental factors, two key questions remain largely unanswered: (1) the intergenerational transmission through which these genetic predispositions are passed from parents to children, and (2) […]Mannan Luo
- Advancing the network theory of mental disorders: A computational model of panic disorder December 23, 2024The network theory of psychopathology posits that mental disorders are systems of mutually reinforcing symptoms. This framework has proven highly generative but does not specify precisely how any specific mental disorder operates as such a system. Cognitive behavioral theories of mental disorders provide considerable insight into how these systems may operate. However, the development of […]Donald J Robinaugh
- Etiology and correlates of alcohol misuse in early midlife December 20, 2024CONCLUSIONS: There is evidence of sex differences in the etiological factors that influence early midlife drinking. After controlling for confounding familial factors, associations between alcohol misuse and poorer early midlife functioning largely remained, suggesting that alcohol misuse may play a role in poorer functioning across several outcomes.Erin Lumpe
- Posttraumatic stress disorder and its cross-generational familial relationship with drug use disorder and alcohol use disorder: an extended Swedish adoption study December 18, 2024Objective: Information on how parental risk for posttraumatic stress disorder (PTSD) relates to their children's risk for drug use disorder (DUD) and alcohol use disorder (AUD) is limited. This study is the first to utilize an extended adoption design which can address questions about the degree of, and sources of, cross-generational and cross-disorder transmission of […]Ananda B Amstadter
- Daily estradiol and progesterone levels moderate genetic and environmental influences on emotional eating across 45 consecutive days in female twins December 4, 2024CONCLUSIONS: Findings are significant in being the first to identify changes in etiologic risk for BE symptoms across daily hormone levels and highlighting novel mechanisms (e.g. hormone threshold effects, regulation of conserved genes) that may contribute to the etiology of BE.Kelly L Klump
- The geographical distribution of the family-genetic risk score for drug use disorder in Sweden and its co-localization with areas of social deprivation December 2, 2024CONCLUSIONS: The geographical distribution of the genetic risk to DUD is quite variable in Sweden. DeSO levels of s.d. and FRGS(DUD) were substantially correlated but also disassociated in a number of regions. The observed patterns were largely consistent with known trends in the human geography of Sweden. This effort lays the groundwork for further studies […]Kenneth S Kendler
- Latent Classes of Comorbid Substance Use and Internalizing and Externalizing Symptoms and Their Stability in U.S. Adults Over Time: Findings from the PATH Study Waves 1-3 (2013-2016) December 2, 2024The co-occurrence of mental disorder symptoms is common in people who use substances. It is unclear whether patterns of comorbidity in a population-based sample of adults are consistent with prior work. The study goal was to identify this comorbidity structure and evaluate its stability over time.Courtney T Blondino
- Age at onset as an index of genetic heterogeneity in major psychiatric and substance use disorders December 2, 2024CONCLUSIONS: Genetic heterogeneity was robustly associated with AAO across our five primary disorders with substantial inter-disorder differences in the observed patterns. In particular, young AAO was associated with maximal genetic homogeneity for SZ and DUD while older AAO had greater genetic homogeneity for MD with AUD falling in between.Kenneth S Kendler
- Childhood trauma is associated with developmental trajectories of EEG coherence, alcohol-related outcomes, and PTSD symptoms December 2, 2024CONCLUSIONS: Childhood assaultive trauma is associated with changes in frontal alpha EEGc and subsequent AUD and PTSD symptoms, though patterns differ by sex and trauma type. EEGc findings may inform emerging treatments for PTSD and AUD.Zoe E Neale
- Polygenic risk scores and help-seeking behaviour in young people with recent onset of mood and psychotic disorders November 30, 2024CONCLUSIONS: Signals of genetic liability are higher in young people who seek help from health services whether or not the problem they are seeking help for meets full-threshold diagnostic criteria for a major mental disorder.Jan Scott
- On the Detection of Population Heterogeneity in Causation Between Two Variables: Finite Mixture Modeling of Data Collected from Twin Pairs November 26, 2024Causal inference is inherently complex and relies on key assumptions that can be difficult to validate. One strong assumption is population homogeneity, which assumes that the causal direction remains consistent across individuals. However, there may be variation in causal directions across subpopulations, leading to potential heterogeneity. In psychiatry, for example, the co-occurrence of disorders such […]Philip B Vinh
- Latent Profiles of Drinking Motives Among Trauma-Exposed Combat Veterans and Civilians: A Comparative Investigation November 25, 2024Trauma exposure and drinking motives (e.g., social, enhancement, coping) are both associated with increased alcohol use and related problems. Studies have frequently investigated this relationship by examining drinking motives, such as drinking to cope with negative affect, in isolation, yet few studies have examined motives simultaneously in trauma-exposed populations. It is also unclear whether the […]Brianna N Jackson
- Family Genetic-Risk Profiles Associated With Divorce November 25, 2024We used Swedish national register data (N = 2,828,777) to examine divorce and its associated patterns of family genetic risk scores (FGRS; personalized measures of genetic risk inferred from diagnoses in relatives) across ten psychiatric disorders: major depression, anxiety disorders, obsessive-compulsive disorder, bipolar disorder, schizophrenia, anorexia nervosa, alcohol use disorder, drug use disorder, ADHD, and […]Jessica E Salvatore
- Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression October 29, 2024Large biobank samples provide an opportunity to integrate broad phenotyping, familial records, and molecular genetics data to study complex traits and diseases. We introduce Pearson-Aitken Family Genetic Risk Scores (PA-FGRS), a method for estimating disease liability from patterns of diagnoses in extended, age-censored genealogical records. We then apply the method to study a paradigmatic complex […]Morten Dybdahl Krebs
- Examining cultural background and the protective effect of marriage on alcohol use disorder in Sweden October 22, 2024CONCLUSIONS: The protective effect of marriage depends on cultural background, with some evidence that increased risks associated with a spouse's foreign background are confounded by family-level factors.Jessica E Salvatore
- Unraveling the Associations Between Voice Pitch and Major Depressive Disorder: A Multisite Genetic Study October 17, 2024Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in […]Yazheng Di
