pubmedvcu

• Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes February 12, 2025
  Objective: Posttraumatic stress disorder (PTSD) and life satisfaction phenotypes are inversely related on a phenotypic level. Given these established relations, researchers have begun to examine possible shared genetic contributions to these outcomes, though the existing genetic literature is sparse and examines these relations via univariate methods. We sought to examine the genetic architecture of PTSD […]
  Shannon E Cusack
• Clinical heterogeneity in major depressive disorder underlies comorbidity with functional disorders February 9, 2025
  The comorbidities between MDD and functional disorders (FDs), such as fibromyalgia (FM), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and irritable bowel syndrome (IBS) remain largely unexplored. We analyzed data from 10,563 lifetime MDD cases (mean age = 50.5 (SD = 11.9), 71.8% female) from the Lifelines Cohort Study. Lifetime MDD symptoms from DSM-5 criterion A were […]
  Nathaniel S Thomas
• Alcohol use in Early Midlife: Findings from the Age 37 Follow-Up Assessment of the FinnTwin12 Cohort February 7, 2025
  This paper provides an overview of the most recent assessment, collected in early midlife, of the FinnTwin12 cohort, a population-based study of Finnish twins born in 1983-1987. The twins were invited to complete an online survey assessing a range of variables, including physical and mental health, alcohol use and problems, other substance use, and early […]
  Megan E Cooke
• The impact of genes and environment assessed longitudinally on psychological and somatic distress in twins from ages 15 to 35 years February 6, 2025
  CONCLUSIONS: The longitudinal trajectory of psychological distress from ages 12 to 35 can thus be largely explained by forward transmission of a stable additive genetic influence, alongside smaller age-specific genetic innovations. This study addresses the limitation of previous research by exhaustively exploring alternative theoretical explanations for the observed patterns in distress symptoms over time, providing […]
  Nathan A Gillespie
• The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years February 6, 2025
  To mark 15 years of the European Journal of Psychotraumatology, editors reviewed the past 15-year years of research on trauma exposure and its consequences, as well as developments in (early) psychological, pharmacological and complementary interventions. In all sections of this paper, we provide perspectives on sex/gender aspects, life course trends, and cross-cultural/global and systemic societal […]
  Miranda Olff
• Triangulated evidence provides no support for bidirectional causal pathways between diet/physical activity and depression/anxiety February 4, 2025
  CONCLUSIONS: Triangulating the evidence across the studies did not provide compelling support for causal effects of diet/physical activity on depression/anxiety or vice versa.
  Kirsten J M van Hooijdonk
• Correction: Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research January 28, 2025
  No abstract
  Na Cai
• Oral Contraceptive Use Is Associated with Significant Differences in MicroRNA Cargo of L1CAM-Associated Extracellular Vesicles January 27, 2025
  Oral contraceptives (OCs) are approved for use after onset of menarche, which is well before brain maturation is complete. OC use may induce biochemical changes in the brain, especially during the neurobiologically dynamic adolescent/young adult years. MicroRNA cargo in L1CAM-associated extracellular vesicles was measured from serum samples collected from young women using the miRCURY LNA […]
  Dana M Lapato
• Comorbidity between internalizing symptoms and disordered eating is primarily driven by genetic influences on emotion regulation in adult female twins January 23, 2025
  Internalizing (e.g., anxiety, depression) and disordered eating (DE; e.g., binge eating, dietary restraint) are highly comorbid, but the mechanisms underlying their comorbidity remain unknown. This was the first twin study to examine whether their co-occurrence may be driven by genetic and/or environmental influences on emotion regulation (ER; ability to modulate duration/intensity of emotions). Analyses included […]
  Megan E Mikhail
• The Splice Index as a prognostic biomarker of strength and function in myotonic dystrophy type 1 January 21, 2025
  BACKGROUNDMyotonic dystrophy type 1 (DM1) is a multisystemic, CTG repeat expansion disorder characterized by a slow, progressive decline in skeletal muscle function. A biomarker correlating RNA mis-splicing, the core pathogenic disease mechanism, and muscle performance is crucial for assessing response to disease-modifying interventions. We evaluated the Myotonic Dystrophy Splice Index (SI), a composite RNA splicing […]
  Marina Provenzano
• Internalizing Psychiatric Symptoms in People With Mosaicism for Trisomy 21 January 17, 2025
  People with mosaicism for trisomy 21 have been shown to exhibit many of the same phenotypic traits present in people with non-mosaic Down syndrome, but with varying symptom severity. However, the behavioral phenotype of people with mosaic Down syndrome (mDS) has not been well characterized. This study aimed to examine the prevalence of self-report and […]
  Ruth C Brown
• Unidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation January 9, 2025
  Cigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which may underpin some of the adverse health sequelae of smoking. However, prior causal analyses with Mendelian Randomisation (MR) have found limited support for such effects. […]
  Madhurbain Singh
• Unraveling the associations between voice pitch and major depressive disorder: a multisite genetic study December 31, 2024
  Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in […]
  Yazheng Di
• Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research December 28, 2024
  Psychiatric disorders are highly comorbid, heritable, and genetically correlated [1-4]. The primary objective of cross-disorder psychiatric genetics research is to identify and characterize both the shared genetic factors that contribute to convergent disease etiologies and the unique genetic factors that distinguish between disorders [4, 5]. This information can illuminate the biological mechanisms underlying comorbid presentations […]
  Na Cai
• The Mechanisms Underlying the Intergenerational Transmission of Substance Use and Misuse: An Integrated Research Approach December 23, 2024
  Substance use and substance use disorders run in families. While it has long been recognized that the etiology of substance use behaviors and disorders involves a combination of genetic and environmental factors, two key questions remain largely unanswered: (1) the intergenerational transmission through which these genetic predispositions are passed from parents to children, and (2) […]
  Mannan Luo
• Advancing the network theory of mental disorders: A computational model of panic disorder December 23, 2024
  The network theory of psychopathology posits that mental disorders are systems of mutually reinforcing symptoms. This framework has proven highly generative but does not specify precisely how any specific mental disorder operates as such a system. Cognitive behavioral theories of mental disorders provide considerable insight into how these systems may operate. However, the development of […]
  Donald J Robinaugh
• Etiology and correlates of alcohol misuse in early midlife December 20, 2024
  CONCLUSIONS: There is evidence of sex differences in the etiological factors that influence early midlife drinking. After controlling for confounding familial factors, associations between alcohol misuse and poorer early midlife functioning largely remained, suggesting that alcohol misuse may play a role in poorer functioning across several outcomes.
  Erin Lumpe
• Posttraumatic stress disorder and its cross-generational familial relationship with drug use disorder and alcohol use disorder: an extended Swedish adoption study December 18, 2024
  Objective: Information on how parental risk for posttraumatic stress disorder (PTSD) relates to their children's risk for drug use disorder (DUD) and alcohol use disorder (AUD) is limited. This study is the first to utilize an extended adoption design which can address questions about the degree of, and sources of, cross-generational and cross-disorder transmission of […]
  Ananda B Amstadter
• Daily estradiol and progesterone levels moderate genetic and environmental influences on emotional eating across 45 consecutive days in female twins December 4, 2024
  CONCLUSIONS: Findings are significant in being the first to identify changes in etiologic risk for BE symptoms across daily hormone levels and highlighting novel mechanisms (e.g. hormone threshold effects, regulation of conserved genes) that may contribute to the etiology of BE.
  Kelly L Klump
• Latent Classes of Comorbid Substance Use and Internalizing and Externalizing Symptoms and Their Stability in U.S. Adults Over Time: Findings from the PATH Study Waves 1-3 (2013-2016) December 2, 2024
  The co-occurrence of mental disorder symptoms is common in people who use substances. It is unclear whether patterns of comorbidity in a population-based sample of adults are consistent with prior work. The study goal was to identify this comorbidity structure and evaluate its stability over time.
  Courtney T Blondino