Publications authored by the Virginia Institute for Psychiatric and Behavioral Genetics are listed below. This is a partial listing pulled from PubMed.gov and contains only a sample of published articles. To see a complete list of all publications by VIPBG, use alt + click on the pubmedvcu link below.
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- Genetic liability estimated from large-scale family data improves genetic prediction, risk score profiling, and gene mapping for major depression October 29, 2024Large biobank samples provide an opportunity to integrate broad phenotyping, familial records, and molecular genetics data to study complex traits and diseases. We introduce Pearson-Aitken Family Genetic Risk Scores (PA-FGRS), a method for estimating disease liability from patterns of diagnoses in extended, age-censored genealogical records. We then apply the method to study a paradigmatic complex […]Morten Dybdahl Krebs
- Examining cultural background and the protective effect of marriage on alcohol use disorder in Sweden October 22, 2024CONCLUSIONS: The protective effect of marriage depends on cultural background, with some evidence that increased risks associated with a spouse's foreign background are confounded by family-level factors.Jessica E Salvatore
- Unraveling the Associations Between Voice Pitch and Major Depressive Disorder: A Multisite Genetic Study October 17, 2024Major depressive disorder (MDD) often goes undiagnosed due to the absence of clear biomarkers. We sought to identify voice biomarkers for MDD and separate biomarkers indicative of MDD predisposition from biomarkers reflecting current depressive symptoms. Using a two-stage meta-analytic design to remove confounds, we tested the association between features representing vocal pitch and MDD in […]Yazheng Di
- Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex October 14, 2024CONCLUSIONS: Our findings identify AUD-associated methylation signals and provide evidence of overlap with previous genetic and methylation studies. These signals may constitute predisposing genetic differences or robust methylation changes associated with AUD, although more work is needed to further disentangle the mechanisms that underlie these associations and their implications for AUD.Julie D White
- The genetics of spatiotemporal variation in cortical thickness in youth October 10, 2024Prior studies have shown strong genetic effects on cortical thickness (CT), structural covariance, and neurodevelopmental trajectories in childhood and adolescence. However, the importance of genetic factors on the induction of spatiotemporal variation during neurodevelopment remains poorly understood. Here, we explore the genetics of maturational coupling by examining 308 MRI-derived regional CT measures in a longitudinal […]J Eric Schmitt
- Prediction of suicide attempt in a Swedish population-based cohort September 24, 2024CONCLUSIONS: These findings illustrate sex-specific pathways to suicide attempt by including risk factors that occur during the development. Results highlight the importance of genetic and family environment but also the prominent role of academic achievement.Séverine Lannoy
- Recent Breakthroughs in Genetic and Brain Structural Correlates of Suicidal Behaviors: A Short Review September 21, 2024Suicide accounts for more than 700,000 deaths annually and is the fourth leading cause of death among individuals aged 15 to 29 years. Despite years of research to understand the etiology and pathophysiology of suicidal behavior, many questions remain unresolved-for example, whether suicidal behavior has a unique genetic or neurobiological basis and how these differ […]Zuriel Ceja
- A Longitudinal Investigation of the Buffering Effects of Resilience on Body Mass Index in Trauma-Exposed College Students September 16, 2024CONCLUSIONS: The positive association between resilience and BMI is not consistent with our hypotheses. Findings suggest that resilience does not buffer against physical health outcomes.Shannon E Cusack
- Feasibility of a Virtual Adaptation of a Yoga Intervention for Veterans with Chronic Pain and Posttraumatic Stress Disorder September 10, 2024Purpose/Objective: This study assessed the feasibility and acceptability of a yoga intervention for veterans with comorbid posttraumatic stress disorder (PTSD) and chronic pain (CP) that was adapted for virtual implementation. Research Method/Design: This pilot feasibility study at a large, mid-Atlantic Veteran's Affairs (VA) Medical Center with veterans with both PTSD and CP examined the adaptation […]Suzzette M Chopin
- The number of episodes of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity September 2, 2024We investigate whether number of episodes (NoEs) meaningfully reflect genetic risk and genetic heterogeneity for five primary disorders-Drug Use Disorder (DUD), Alcohol Use Disorder (AUD), Major Depression (MD), Bipolar Disorder (BD), and Schizophrenia (SZ) ascertained from Swedish population registries. We utilize Genetic Risk Ratios (GRR)-defined as the ratio of the genetic risk for secondary disorders […]Kenneth S Kendler
- Assessing shared psychological constructs as risk factors in comorbid PTSD-AUD combat-exposed male veterans August 29, 2024PTSD and AUD are frequently comorbid post-trauma outcomes. Much remains unknown about shared risk factors as PTSD and AUD work tends to be conducted in isolation. We examined how self-report measures of distress tolerance (DT), experiential avoidance (EA), and drinking motives (DM) differed across diagnostic groups in white, male combat-exposed veterans (n = 77). A […]Angela J Zaur
- Characterizing Long COVID in Children and Adolescents August 28, 2024CONCLUSIONS AND RELEVANCE: This study developed research indices for characterizing PASC in children and adolescents. Symptom patterns were similar but distinguishable between the 2 groups, highlighting the importance of characterizing PASC separately for these age ranges.Rachel S Gross
- Racial and ethnic differences in comorbid psychosis: a population-based study August 14, 2024CONCLUSION: There were different patterns of associations by race and ethnicity for psychosis and comorbid psychosis. The lower prevalence of comorbid psychosis in non-White groups may be due to underdiagnosis or underreporting of other mental disorders.Mariam Sankoh
- A twin analysis to estimate genetic and environmental factors contributing to variation in weighted gene co-expression network module eigengenes August 10, 2024Multivariate network-based analytic methods such as weighted gene co-expression network analysis are frequently applied to human and animal gene-expression data to estimate the first principal component of a module, or module eigengene (ME). MEs are interpreted as multivariate summaries of correlated gene-expression patterns and network connectivity across genes within a module. As such, they have […]Nathan A Gillespie
- Peer Social Genetic Effects and the Etiology of Substance Use Disorders, Major Depression, and Anxiety Disorder in a Swedish National Sample August 7, 2024CONCLUSIONS: The genetic makeup of adolescents' peers has long-reaching consequences on risks for drug use disorder, AUD, major depression, and anxiety disorder. Individuals at high genetic risk are more sensitive to social genetic effects. Alternative hypotheses such as sociodemographic stratification, exposure to affected peers, and genetic predispositions for educational attainment did not explain the risk […]Jessica E Salvatore
- Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins August 2, 2024INTRODUCTION: The amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal hypotheses regarding the direction of causation between Aβ40 and Aβ42 and total Tau (t-Tau) plasma biomarkers.Nathan A Gillespie
- A Bivariate Twin Study of Lifetime cannabis Initiation and Lifetime Regular Tobacco Smoking Across Three Different Countries July 30, 2024Regular cigarette smoking and cannabis consumption are strongly positively related to each other, yet few studies explore their underlying variation and covariation. We evaluated the genetic and environmental decomposition of variance and covariance of these two traits in twin data from three countries with different social norms and legislation. Data from the Netherlands Twin Register, […]Stephanie Zellers
- Comorbidity and sex differences in functional disorders and internalizing disorders July 30, 2024CONCLUSION: Studies that aim to explain sex differences and the comorbidity of specific combinations of IDs and FDs will be an important contribution to understanding the etiology of these conditions.Nathaniel S Thomas
- On the detection of population heterogeneity in causation between two variables: Finite mixture modeling of data collected from twin pairs July 23, 2024Causal inference is inherently complex, often dependent on key assumptions that are sometimes overlooked. One such assumption is the potential for unidirectional or bidirectional causality, while another is population homogeneity, which suggests that the causal direction between two variables remains consistent across the study sample. Discerning these processes requires meticulous data collection through an appropriate […]Philip Vinh
- The Prediction of Diagnostic Change From Bipolar Disorder to Schizophrenia and Schizophrenia to Bipolar Disorder in a Population-Based, Longitudinal, National Swedish Sample July 22, 2024CONCLUSIONS: Diagnostic conversion of BD→SZ and SZ→BD are not rare, are moderately predictable, and should likely be accounted for in many research designs.Kenneth S Kendler
