pubmedvcu

• Within-Person Changes in Daily Ovarian Hormone Levels Influence Genetic Effects on Emotional Eating in Women September 17, 2025
  CONCLUSION: Cyclic, within-person changes in ovarian hormones may contribute to phenotypic changes in dysregulated eating across the menstrual cycle by dynamically regulating expression of underlying genetic risk. Genetic influences may be particularly pronounced under the hormonal conditions characteristic of the mid-luteal phase (i.e., moderate estradiol and progesterone).
  Megan E Mikhail
• Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes September 17, 2025
  We performed a genome-wide association meta-analysis (GWAMA) of 290,134 attention-deficit/hyperactivity disorder (ADHD) symptom measures of 70,953 unique individuals from multiple raters, ages and instruments (ADHD(SYMP)). Next, we meta-analyzed the results with a study of ADHD diagnosis (ADHD(OVERALL)). ADHD(SYMP) returned no genome-wide significant variants. We show that the combined ADHD(OVERALL) GWAMA identified 39 independent loci, of […]
  Camiel M van der Laan
• Causal Analyses of Associations Between Brain Structure and Suicide Attempt in Adulthood and Late Childhood September 9, 2025
  CONCLUSION: Brain markers of suicide risk may be instantiated differently in adults compared with older children, though lower ACT may be causally related to psychopathology associated with suicidality in these youth.
  Yi Zhou
• Evidence for Genetic Nurture Effects on Substance Use September 5, 2025
  Substance use runs in families. Beyond genetic transmission, parental genetics can indirectly influence offspring substance use through the rearing environment, known as "genetic nurture". This study utilized transmitted and non-transmitted polygenic scores to investigate genetic nurture effects on tobacco, alcohol and cannabis use in up to 15,863 adults with at least one genotyped parent from […]
  Mannan Luo
• Longitudinal Associations between Well-Being and Academic Achievement throughout the COVID-19 Pandemic: Testing the Moderating Role of Academic Stress among First-Generation and Continuing College Students September 2, 2025
  First-generation and ethnic-racial minoritized college students experience greater academic disparities, but limited work has focused on intersectional experiences underlying academic achievement in higher education during the COVID-19 pandemic over time. The current longitudinal study examined the associations between various forms of well-being (i.e., emotional, psychological, and social) at T1 (Time 1; acute pandemic) predicting academic […]
  Chelsea Derlan Williams
• The impact of investing in private clinics and pharmacies on modern contraceptive uptake: an agent-based model of a segmented market September 2, 2025
  CONCLUSIONS: The factors that family planning policies should target to maximize their effect on modern contraceptive prevalence differ for markets characterized by different social contexts. Success of a policy will require policymakers' attention to the relative preferences for low price, short wait time, short travel time, and quality among population subgroups. Our study results suggest […]
  Mingxin Chen
• Deep Phenotyping at Scale: Study Protocol for the Korean Mood Disorder Genetic Study-Depression (KOMOGEN-D) August 25, 2025
  A core challenge in the genetic analysis of major depressive disorder (MDD) is how to recruit large numbers of stringently diagnosed cases with sufficient information to explore the interplay between genetic and environmental risk factors and evaluate genetic influences on putative MD subtypes and key clinical features. Currently, most genome-wide association studies of MDD rely […]
  Sooyeon Min
• Phenome-wide association study of male and female sex chromosome trisomies in 1.5 million participants of MVP, FinnGen, and UK Biobank August 21, 2025
  Sex chromosome trisomies (SCTs) are the most common whole-chromosome aneuploidy in humans. Yet, our understanding of the prevalence and associated health outcomes is largely driven by observational studies of clinically diagnosed individuals, resulting in a disproportionate focus on 47,XXY and associated hypogonadism. We analyzed microarray intensity data of sex chromosomes for 1.5 million individuals enrolled […]
  Shanlee M Davis
• Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits August 20, 2025
  CONCLUSIONS: Our results suggest that combining the wide availability of diagnostic EHR data with nuanced criterion-level analyses of DSM tobacco use disorder may produce new insights into the genetics of this disorder.
  Emma C Johnson
• The Impact of the Parental Patterns of Morbidity and Comorbidity in the Cross-Generational Transmission of Risk for Major Depression and Alcohol Use Disorder August 14, 2025
  To further understand the inter-relationship of the familial transmission of major depression (MD) and alcohol use disorder (AUD), we examine, via a multivariable Cox proportional hazards model, risks for AUD and MD in 1,244,516 individuals born in Sweden from 1970 to 1990 to intact mother-father pairs as a function of parental diagnoses of MD and/or […]
  Kenneth S Kendler
• The outcome of major psychiatric and substance use disorders as an index of genetic risk and genetic heterogeneity August 14, 2025
  CONCLUSIONS: Despite important differences between our primary disorders, social and psychiatric outcomes are often robust indices of genetic risk and can reflect the levels of genetic heterogeneity.
  Kenneth S Kendler
• Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects August 12, 2025
  Psychiatric conditions share common genes, but mechanisms that differentiate diagnoses remain unclear. We present a multidimensional framework for functional analysis of rare copy number variants (CNVs) across 6 diagnostic categories, including schizophrenia (SCZ), autism (ASD), bipolar disorder (BD), depression (MDD), PTSD, and ADHD (N = 574,965). Using gene-set burden analysis (GSBA), we tested duplication (DUP) […]
  Worrawat Engchuan
• Genetic risk effects on psychiatric disorders act in sets August 8, 2025
  Genetic studies of psychiatric disorders have typically assumed that all genetic effects contribute additively to disease liability. However, it is likely that psychiatric disorders have unrecognized subtypes, where synergistic sets of risk variants co-occur within certain cases more than expected under additivity. The existence of synergistic sets induces a structured form of statistical interactions called […]
  Jolien Rietkerk
• A Call for Inclusion: Children With Intellectual Disabilities in Trauma Treatment Research August 7, 2025
  CONCLUSIONS: The evidence base for the ISTSS clinical care guidelines of child PTSD treatment is not representative of children with ID. Improved documentation of inclusion/exclusion criteria, reporting of disability as a demographic characteristic, and inclusion of children with ID in PTSD treatment trials are needed to improve representation of children with ID in PTSD research.
  Zackary F Moore
• The Genetics of Cerebellar Structure and Associations With Cognitive Performance: A Twin Magnetic Resonance Imaging Study August 6, 2025
  The cerebellum, traditionally associated with motor control, is increasingly recognized for its involvement in higher-order cognitive functions. However, the role of cerebellar subregions in cognition remains underexplored, as are the roles of genetic factors on cerebellar structure and brain-behavioral associations. The primary goal of this study was to investigate the relationship between cerebellar subregion volumes […]
  Gretchen Lutz
• Longitudinal predictors of alcohol use and problems during the COVID-19 pandemic in an at-risk veteran sample August 4, 2025
  Background: Individuals with pre-existing heavy alcohol use, prior traumatic exposures, and psychiatric disorders were considered an at-risk group for increased alcohol use and problems in the context of the COVID-19 pandemic.Objective: This study recruited from a multi-centre longitudinal cohort study of US military service members/veterans with combat exposure to examine the trajectories of alcohol use […]
  Angela J Zaur
• Identifying different phenotypes in acute fulminant myocarditis patients treated with venoarterial extracorporeal membrane oxygenation by latent class analysis August 2, 2025
  CONCLUSIONS: Using LCA, we identified three clinical phenotypes of AFM patients treated with VA-ECMO. These may reflect different pathophysiological processes in this patient population. Our findings may help identify treatment targets and select patients for future clinical trials.
  Haiming Niu
• Proportional Sedation for Persistent Agitated Delirium in Palliative Care: A Randomized Clinical Trial July 31, 2025
  CONCLUSIONS AND RELEVANCE: The results of this randomized clinical trial indicate that proactive use of scheduled sedatives, particularly lorazepam-based regimens, may reduce persistent restlessness and/or agitation in patients with advanced cancer and delirium in the palliative care setting.
  David Hui
• Measuring the Associations Between Brain Morphometry and Polygenic Risk Scores for Substance use Disorders in Drug-Naive Adolescents July 25, 2025
  Substance use has been associated with differences in adult brain morphology; however, it is unclear whether these differences precede or are a result of substance use substance use. We investigated the impact of polygenic risk scores (PRSs) for cannabis use disorder (CUD) and general substance use and substance use disorder liability (SU/SUD) on brain morphology […]
  Sydney Kramer
• Profiles of Genetic Risks for Psychotic Disorders July 9, 2025
  CONCLUSIONS AND RELEVANCE: In a Swedish population, none of the 4 disorders appeared, from a genetic perspective, to be subtypes of SZ, BD, or MD. Further genetics research on the syndromes of DD, AP, PNOS, and SAD have much to teach about the relationship between dimensions of genetic risks and the clinical presentation and course […]
  Kenneth S Kendler