pubmedvcu

• The Impact of a Registry-Based Environmental Risk Score on Episodes of Alcohol Use Disorder and Drug Use Disorder in Swedish National Samples May 8, 2025
  CONCLUSIONS: Valid measures of environmental risks that predispose to AUD and DUD can be assessed from SLEs obtained from high quality national registry data. Importantly, this method avoids prior assessment problems of accurate dating and recall bias and can be performed in large samples.
  Kenneth S Kendler
• The relationship between parenting behavior, suicidal ideation, and suicide attempt across two population-based samples of adolescents May 7, 2025
  We examined the relationship between parenting, suicidal ideation (SI), and the transition from SI to suicide attempt (SA), and whether parenting behaviors moderate the associations of genetic liability for SA and/or painful and provocative events (PPEs) with SA risk. Participants included 6153 adolescents (48.3 % female, M(age) at baseline = 9.47 years, followed over 3 […]
  Mallory Stephenson
• Familial coaggregation and shared familiality of functional and internalizing disorders in the Lifelines cohort May 2, 2025
  CONCLUSIONS: There is a clear familial component to FDs, which is partially shared with IDs. This suggests that IDs and FDs share both genetic and family-environmental risk factors. Of the FDs, ME/CFS is most closely related to IDs.
  Martje Bos
• A multivariate Swedish national twin-sibling study in women of major depression, anxiety disorder, fibromyalgia, and irritable bowel syndrome April 28, 2025
  CONCLUSIONS: In women, FSDs and IPDs shared a moderate proportion of their genetic risk factors, greater for IBS than for FM. However, the genetic sharing between IBS and FM was less than between MD and AD, suggesting that FSDs do not form a highly genetically coherent group of disorders. The shared environment made a modest […]
  Kenneth S Kendler
• The roles of adverse childhood experiences and genetic liability in risk for suicidal thoughts and behaviors: A factor analytic approach April 28, 2025
  Adverse childhood experiences are consistently implicated in risk for suicidal thoughts and behaviors (STB). However, the nature of those experiences and their specific associations with STB remain unclear. The diathesis-stress model also suggests that the influence of adverse experiences depends on one's genetic liability, though results using measures of aggregate genetic risk need additional empirical […]
  Séverine Lannoy
• Financial Stressors and Risk of Suicidal Behavior in a Swedish National Cohort April 22, 2025
  Although financial stressors are implicated as risk factors for suicidal behavior, these associations might be confounded by other factors. Furthermore, a move toward high-risk subgroup definition is necessary. The authors used Swedish national registry data to examine the associations between receipt of social welfare, unemployment benefits, or early retirement (N = 627,745-2,260,753) with suicidal behavior […]
  Alexis C Edwards
• Exploring the implications of case selection methods for psychiatric molecular genetic studies April 20, 2025
  Researchers selecting probands for molecular genetic studies confront a range of sampling issues with modest empirical guidance. In this paper, using cases of major depression (MD), anxiety disorders (AD) alcohol use disorder (AUD), drug use disorder (DUD), bipolar disorder (BD) and schizophrenia (SZ) from a large population cohort of all native Swedes born 1940-2003, we […]
  Kenneth S Kendler
• The moderation of genetic risk for ten major psychiatric and substance use disorders by the genetic aptitude for educational attainment April 17, 2025
  We seek to clarify the impact of the Genetic Aptitude for Educational Attainment (GAEA) on risk for 10 psychiatric disorders divided into 4 groups: Internalizing, Externalizing, Eating/Compulsive and Psychotic. Educational attainment and psychiatric and substance use disorder information were obtained from national Swedish registries. GAEA and disorder-specific family genetic risk score (FGRS) were calculated from […]
  Kenneth S Kendler
• Genetic and Environmental Influences on Fear Learning and Generalization April 2, 2025
  Understanding how excessive fear responses develop and persist is critical. Research using laboratory models of fear learning offers valuable insights on etiology. In this study, the influence of genetic and environmental etiology of baseline startle response and fear learning was examined, focusing on fear acquisition and generalization processes using the fear conditioning paradigm measuring fear-potentiated […]
  Christina M Sheerin
• Trans-ancestry Genome-Wide Analyses in UK Biobank Yield Novel Risk Loci for Major Depression March 10, 2025
  Most genome-wide association studies (GWASs) of depression focus on broad, heterogeneous outcomes, limiting the discovery of genomic risk loci specific to major depressive disorder (MDD). Previous UK Biobank (UKB) studies had limited ability to pinpoint MDD-associated loci due to a smaller sample with strictly defined MDD outcomes and further exclusion of many participants based on […]
  Madhurbain Singh
• What is the role of paternal genetic transmission on risk for PTSD and internalizing and externalizing disorders? March 10, 2025
  CONCLUSIONS: This study is the first to show cross-generation genetic transmission for PTSD using the MHSFDF design. The pattern of cross-disorder genetic risk broadly supported an internalizing versus externalizing disorder split.
  Ananda B Amstadter
• The development of an environmental risk score using Swedish National Registers and its impact on subsequent episodes of major depression March 7, 2025
  CONCLUSIONS: Valid measures of SLEs that predispose to risk for MD can be assessed from high-quality registry data. While not all event categories (e.g. interpersonal or romantic difficulties) can be assessed, this method avoids problems with accurate dating and recall bias and can be performed in very large samples.
  Kenneth S Kendler
• The familial aggregation and co-aggregation of drug use disorder and alcohol use disorder in siblings of affected individuals born 1950-1990: A birth cohort exposed to rising rates of drug use disorder March 5, 2025
  CONCLUSIONS: The factors that drove upward population rates of DUD in Sweden (e.g. increased availability, reduced stigma) produced much stronger effects in high-risk subjects (siblings of DUD and AUD probands) than in normal risk groups (siblings of controls), thereby increasing familial aggregation of DUD. However, parallel declines in AUD rates in high-risk versus normal-risk siblings […]
  Kenneth S Kendler
• Are Depressive and Anxiety Symptoms Differentially Associated with Alcohol Use Behaviors: Multivariate Behavioral Genetic Analyses February 27, 2025
  This study examined whether adolescent depressive and anxiety symptoms were differentially associated with alcohol use behaviors, and how these associations were explained by genetic, shared, and nonshared environmental influences. Participants were from the Nonshared Environment and Adolescent Development project of same-sex twin/sibling pairs from 720 families. Twin/sibling depressive and anxiety symptoms were measured by self-report […]
  Tong Chen
• Longitudinal analysis of the ABCD® study February 25, 2025
  The Adolescent Brain Cognitive Development® (ABCD) Study provides a unique opportunity to investigate developmental processes in a large, diverse cohort of youths, aged approximately 9-10 at baseline and assessed annually for 10 years. Given the size and complexity of the ABCD Study, researchers analyzing its data will encounter a myriad of methodological and analytical considerations. […]
  Samuel W Hawes
• Associations between worry about mental and physical health and the use of face masks: Exploring discrimination as a moderator among Black Americans February 24, 2025
  Given the disproportionate impact of COVID-19, it is important to understand factors that may underlie Black American emerging adults' adherence to safety guidelines that could potentially reduce spread of illness and hospitalization. The current study examined how COVID-19 worry about mental health (CWMH) and COVID-19 worry about physical health (CWPH) predicted use of face masks, […]
  Chloe J Walker
• Multi-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits February 20, 2025
  Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement. We conducted a genome-wide association study of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry, 10,231 of African ancestry, 3,746 of East Asian ancestry) and compared the results to […]
  Emma C Johnson
• Prevalence and disease risks for male and female sex chromosome trisomies: a registry-based phenome-wide association study in 1.5 million participants of MVP, FinnGen, and UK Biobank February 20, 2025
  Sex chromosome trisomies (SCT) are the most common whole chromosome aneuploidy in humans. Yet, our understanding of the prevalence and associated health outcomes is largely driven by observational studies of clinically diagnosed cases, resulting in a disproportionate focus on 47,XXY and associated hypogonadism. We analyzed microarray intensity data of sex chromosomes for 1.5 million individuals […]
  Shanlee M Davis
• Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes February 12, 2025
  Objective: Posttraumatic stress disorder (PTSD) and life satisfaction phenotypes are inversely related on a phenotypic level. Given these established relations, researchers have begun to examine possible shared genetic contributions to these outcomes, though the existing genetic literature is sparse and examines these relations via univariate methods. We sought to examine the genetic architecture of PTSD […]
  Shannon E Cusack
• Clinical heterogeneity in major depressive disorder underlies comorbidity with functional disorders February 9, 2025
  The comorbidities between MDD and functional disorders (FDs), such as fibromyalgia (FM), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and irritable bowel syndrome (IBS) remain largely unexplored. We analyzed data from 10,563 lifetime MDD cases (mean age = 50.5 (SD = 11.9), 71.8% female) from the Lifelines Cohort Study. Lifetime MDD symptoms from DSM-5 criterion A were […]
  Nathaniel S Thomas