Posts Tagged 'genetic risk'

Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Schizophrenia (SCZ) is a severe, clinically heterogeneous psychiatric disorder with a population prevalence of ~1% [1]. Twin, family, and adoption studies consistently show a strong genetic component, with heritability estimates of around 0.75–0.80 [2,3,4,5,6], and family history (FH) remains the strongest risk factor for developing SCZ [7]. Despite high heritability, ~2/3 of SCZ cases report no FH of psychotic illness, and most subjects with a positive FH (FH+) report only a single affected relative [8, 9], concordant with the rates ...

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Genetic overlap between major depression and obesity in some patients

Genetic overlap between major depression and obesity in some patients

NEW YORK (Reuters Health) – Patients with major depressive disorder who experience increases in appetite, weight, or both have a higher genetic risk for obesity-related traits such as high body-mass index (BMI) and elevated levels of leptin and inflammation, researchers suggest.

“As clinicians, we are well aware that depression is highly heterogeneous, and patients with the same diagnosis of major depressive disorder may present with very different symptom profiles,” Dr. Yuri Milaneschi of VU University Medical Center Amsterdam in the Netherlands ...

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