Posts Tagged 'schizophrenia'

Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Schizophrenia (SCZ) is a severe, clinically heterogeneous psychiatric disorder with a population prevalence of ~1% [1]. Twin, family, and adoption studies consistently show a strong genetic component, with heritability estimates of around 0.75–0.80 [2,3,4,5,6], and family history (FH) remains the strongest risk factor for developing SCZ [7]. Despite high heritability, ~2/3 of SCZ cases report no FH of psychotic illness, and most subjects with a positive FH (FH+) report only a single affected relative [8, 9], concordant with the rates ...

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Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

In the last decade, genome-wide association studies (GWAS) have identified a large number of common genetic risk variants associated with complex human phenotypes (Visscher et al., 2017). Many genetic variants identified by GWAS exhibit varying degrees of genetic pleiotropy (Solovieff et al., 2013), and investigating the nature of these shared genetic risks is important for improving our understanding of the etiology and underlying genetic architecture of complex human disorders. A widely used method for assessing the genetic relationship between two ...

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Postdoctoral Training in Psychiatric and Statistical Genetics

Postdoctoral Training in Psychiatric and Statistical Genetics

The Virginia Institute for Psychiatric and Behavioral Genetics is pleased to invite applications for postdoctoral training with a focus on mental health. The Institute offers a rich interdisciplinary training environment. Institute faculty include leaders in the fields of behavioral and psychiatric genetics and represent a wide range of scientific backgrounds from molecular and statistical genetics to epidemiology, psychology, and psychiatry.

Currently funded research at VIPBG includes molecular-genetic studies of schizophrenia, major depression, anxiety and panic disorders, PTSD, substance use disorders ...

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Major mental illnesses unexpectedly share brain gene activity, raising hope for better diagnostics and therapies

Major mental illnesses unexpectedly share brain gene activity, raising hope for better diagnostics and therapies

Mental illness affects one in six U.S. adults, but scientists’ sense of the underlying biology of most psychiatric disorders remains nebulous. That’s frustrating for physicians treating the diseases, who must also make diagnoses based on symptoms that may only appear sporadically. No laboratory blood test or brain scan can yet distinguish whether someone has depression or bipolar disorder, for example.

Now, however, a large-scale analysis of postmortem brains is revealing distinctive molecular traces in people with mental illness. This week, an ...

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Featured Faculty: B. Todd Webb, Ph.D.

Featured Faculty: B. Todd Webb, Ph.D.

By Jessica Bourdon

Dr. B. Todd Webb, Ph.D. is an Assistant Professor at the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University. His interest in behavioral genetics developed gradually over his academic career. He majored in biology at VCU but always had an interest in genetics. Over time, he became passionate about how complex systems work and later obtained his Ph.D. in human genetics. This allowed him to hone his skills while providing him ...

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Featured Postdoc: Jeffry Alexander, Ph.D.

Featured Postdoc: Jeffry Alexander, Ph.D.

By Jessica Bourdon

Jeffry Alexander, Ph.D. is a post-doctoral fellow at the Virginia Institute for Psychiatric and Behavioral Genetics. His interests in psychiatric genetics developed in an indirect fashion. After practicing as a veterinarian for seven years, he decided a change was in order and began looking for a career with more of a public health impact. Therefore, he pursued a master’s degree in public health (MPH) at VCU.

While completing his master’s degree, he worked in Dr. Brien ...

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Methodological Development And Statistical Genetics

Methodological Development And Statistical Genetics

By Elizabeth Long

Silviu-Alin Bacanu, Ph.D. is an Associate Professor in the Department of Psychiatry. His interests in psychiatric genetics began while he was completing his PhD in statistics from the University of Pittsburgh. Upon graduating, he pursued these interests by working in psychiatric genetics research at the University of Pittsburgh Medical Center for several years, where he worked with on a variety of phenotypes, including schizophrenia, eating disorders, and Alzheimer’s disease. Subsequently, he obtained a research ...

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Featured Postdoc: Anna Docherty, Ph.D.

Featured Postdoc: Anna Docherty, Ph.D.

By Elizabeth Long

Anna Docherty, Ph.D. recently completed her postdoc training at the Virginia Institute for Psychiatric and Behavioral Genetics. In two years at VIPBG, she secured an NIMH K01 and NARSAD Young Investigator Award to study the molecular genetics of schizophrenia and schizotypy, and published several papers using both biometrical and molecular genetics approaches. She just began a tenure-track professorship in Psychiatry and Human Genetics at the University of Utah, and her work dovetails extremely well ...

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Whole Genome Sequencing In Multiplex Families

Whole Genome Sequencing In Multiplex Families

By Elizabeth Long

Brien Riley, Ph.D. is Associate Professor in the Department of Psychiatry. He is a molecular geneticist interested in identifying genes that contribute to variation in the brain, central nervous system function, and psychiatric illness risk and behavior. These interests developed after he completed his bachelor’s degree in psychology, as a result of his dissatisfaction with the field’s way of approaching brain function and dysfunction. He was frustrated “because the field ...

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VCU, Swedish study finds schizophrenia risk better predicted by deviation in intelligence from family

VCU, Swedish study finds schizophrenia risk better predicted by deviation in intelligence from family

The degree to which an individual deviates in intelligence from their family is a more accurate predictor of schizophrenia development than the individual’s intelligence alone, according to a new study conducted by researchers at Virginia Commonwealth University and Lund University in Sweden.

The study confronts the conventional wisdom that low intelligence alone is a sufficient risk factor for schizophrenia development, going further to say that the risk for schizophrenia development is more accurately indexed by the degree to which an individual ...

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