Multivariate Phenotyping

Time Speaker Topic Presentation Notes/Examples
09:00 – 10:30 Kenneth Kendler Statistical Genetics of Substance Use Introduction
11:00 – 12:30 Hermine Maes / Roseann Peterson Review Multivariate Genetic Analysis Review OpenMx Helper Functions
Causes of CoVariation
Gen Epi Helper Functions
MultiTwinRawCon.R
usski.rec
MultiTwinRawOrdEx.R
selVATSPSUD.dat
MultiTwinRawOrd.output
BivCCCTwinRawOrdEx.R
selVA30.dat
01:30 – 02:30 Michael Neale / Ryne Estrabrook Genetic Factor Analysis vs Item Response Model FactorScoreConSim.R
iqnl.rec
MultiTwinRawConFScore.R
03:00 – 04:00 Michae Neale / Shaunna Clark Measurement Invariance/ Underreporting Measurement Invariance octomult_10aug2010.rdata
MeasurementInvarianceExample.R

Genes, Environment & Development

Time Speaker Topic Presentation Notes/Examples
08:00 – 09:00 Timothy York R Review Functions4StatisticalAnalysis.R
disease.csv
09:00 – 10:30 Lindon Eaves Developmental Genetic Models Development
Presentation
Generate.R
11:00 – 12:30 Nathan Gillespie Genetic Growth Mixture Models & Time Series Longitudinal Modeling
Presentation
LongitudinalTwinAnalysisCon.R
jepq_con.dat
LongitudinalTwinAnalysisOrd.R
jepq_ord.txt
Practical.R
01:30 – 03:00 Shaunna Clark / Ryne Estabrook Mixture Modeling/ Multi-Level Models Mixture & Multilevel Modeling
Presentation
Programming Growth Mixture Models in OpenMx
gmm.R
03:30 – 05:00 Daniel Dick / Timothy York Genotype Environment Interaction & Correlation Gene-Environment Interaction & Correlation
Presentation
VCxEnvSimulated STUDENT.R
GxEdata.csv

SEM & Measured Genes

Time Speaker Topic Presentation Notes/Examples
09:00 – 10:30 Steven Boker / Timothy Brick Dynamical Models Introduction to Dynamical Systems Analysis GOLDfunctions.R
1stOrderUnivariateLDE.R
2ndOrderUnivariateLDE.R
LDEUnivariateExample.dat
LDE1stOrderUnivariate.csv
11:00 – 12:00 Hermine Maes SEM with Measured Genes SEM with Measured Genotypes UnivTwinACEGRawOrdEx.R
selVATS.dat
12:00 – 12:30 Hao Wu Issues with Likelihood Ratio Tests Nonstandard Likelihood Ratio Test in ACE Models EvsACEsimulation.R
CEvsACEsimulation.R
01:30 – 03:00 Amy Adkins BLUPS: Best Linear Unbiased Prediction BLUPs for omics nida_maus_examp_blups.R
03:30 – 05:00 Michael Bowers Animal Models Addiction Animal “Models”

Integrative Approaches

Time Speaker Topic Presentation Notes/Examples
09:00 – 09:30 Edwin van den Oord Statistical Molecular Genetic Approaches Introduction to Molecular Part NIDA workshop
09:30 – 10:30 Michael Neale / Benjamin Neale Association & Plink Whole genome association software tutorial
Presentation
11:00 – 12:30 Jozsef Bukszar Controlling False Discoveries & Data Integration Integrating heterogeneous genetic data sets based on rigorous mathematical foundation
Presentation
01:30 – 03:00 Joseph McClay Behavioral Metabolomics Behavioral Metabolomics
Presentation
03:30 – 05:00 Edwin van den Oord Pharmacogenomics & Personalized Medicine Biomarkers and Personalized Medicine

Next-Generation Sequencing

Time Speaker Topic Presentation Notes/Examples
09:00 – 10:00 Gregory Buck Introduction to Next-Generation Sequencing Introduction to DNA Sequencing Technologies
Presentation
10:00 – 11:00 Guimin Gao Association Tests for Rare Variants Association Tests for Rare Variants Using Sequence Data
Presentation
11:30 – 01:00 Michael Neale / Benjamin Neale Exome Sequencing & P-seq Autism exome sequencing: design, data processing and analysis
Presentation
02:00 – 03:00 Karolina Aberg Methylation Next-generation sequencing technology to study genome wide methylation pattern
03:30 – 05:00 Tobias Guennel / Mark Reimers RNA-seq & Chip-seq Data Analysis for High-Throughput Sequencing
Presentation
NIDALab.zip
RNASeqLab.pdf

Extended Pedigree Program – Part 01

Time Speaker Topic Presentation Notes/Examples
09:00 – 10:30 Lindon Eaves Twin-Family and Extended Pedigrees Intro Extended Twin-Kinship Designs
Presentation
Some references
11:00 – 01:00 Hermine Maes ML Correlations in Extended Pedigrees ML Correlations ETC5x.R
ETC10x.R
ETC88x.R
MZM
DZM
MZF
DZF
DZOS
htusmzm.rec
htusdzm.rec
htusmzf.rec
htusdzf.rec
htusdzo.rec
02:00 – 03:00 Hermine Maes ET Designs ET Designs Truett et al. 1994
Eaves et al. 1999
Maes et al. 1999
Eaves et al. 2005
Maes et al. 2006
Maes et al. 2007
Keller et al. 2009
Maes et al. 2009
03:30 – 05:00 Hermine Maes ET Designs Practical ET10x.R

Extended Pedigree Program – Part 02

Time Speaker Topic Presentation Notes/Examples
09:00 – 10:30 Hermine Maes Extended Pedigrees Extended Pedigrees ET88x2pa.R
11:00 – 12:30 Hermine Maes Practical