Research

Dr. Kaitlin Bountress and other MPIs awarded R34 through NIH/NIDA

Dr. Kaitlin Bountress and other MPIs awarded R34 through NIH/NIDA

Dr. Kaitlin Bountress, along with other MPIs Drs. Gretchen Neigh, Peter Hamilton, and Mathew Banks, were awarded a R34 through NIH/NIDA R34 (R34DA061267).
This project seeks to establish a multidisciplinary and functionally diverse team and generate preliminary data across-species (i.e., in rat, human data) in order to improve our understanding of behavioral biomarkers and genetic risk factors for neurocognitive behaviors related to substance use disorder risk. The ultimate goal of this line of work is to improve our ...

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VCU Researcher Awarded DOD Grant to Identify Genetic Risk Factors for Persistent Concussion Symptoms and PTSD

VCU Researcher Awarded DOD Grant to Identify Genetic Risk Factors for Persistent Concussion Symptoms and PTSD

Dr. Christina Sheerin, along with other MPIs Dr. Amstadter and Dr. Disner (University of Minnesota) were awarded a 3-year Investigator Initiated grant through the Traumatic Brain Injury and Psychological Health Research Program of the Department of Defense (TP230074).

This project leverages a longitudinal registry study and biorepository of military service members and veterans and seeks to use novel genetic approaches to characterize the genetic architecture and functional consequences of genetic risk on persistent post concussive symptoms, PTSD, and AUD ...

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Dr. Amanda Elswick Gentry Awarded K01 From NIH NIAAA

Dr. Amanda Elswick Gentry Awarded K01 From NIH NIAAA

Dr. Amanda Elswick Gentry, Ph.D. was awarded a K01 from the NIH NIAAA (K01AA031748). A five-year professional and research development award mentored by Dr. Ken Kendler, MD, this project will investigate the interacting genetic and environmental effects contributing to alcohol use disorders with co-morbid major depressive disorder.

This research leverages ten biobank-scale data collections and includes methodological aims for the development of machine learning innovations to predict missing and unmeasured alcohol-related outcomes, as well as specific focus on ...

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VIPBG Faculty Receive Funding to Study AUD and PTSD Through NIAAA R01 Grant

VIPBG Faculty Receive Funding to Study AUD and PTSD Through NIAAA R01 Grant

Drs. Ananda Amstadter (VCU) and Abigail Lott (Emory) were recently funded to study models of comorbidity between alcohol use disorder (AUD) and post traumatic stress disorder (GTP) through a new NIAAA R01 (AA030549). They are joined by Co-Is from VCU (Drs. Sheerin and Bacanu), Emory (Drs. Micholopous, Ressler), SUNY (Dr. Peterson), and University of Windsor (Dr. Rappaport). AUD and PTSD commonly co-occur.

Directional models of comorbidity exist, self-medication ...

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Drs. Elizabeth Prom-Wormley and Hermine Maes Receive Funding for Their Resist! Project

Drs. Elizabeth Prom-Wormley and Hermine Maes Receive Funding for Their Resist! Project

Drs.Elizabeth Prom-Wormley and Hermine Maes recently received funding for their Resist! Project (R01 DA054313). The goal of this project is to index individual resistance to psychoactive substance use (SU) during adolescence and use the indices to identify factors influencing resistance into early middle adulthood, with a special focus on potentially modifiable factors.

We will also use a concept mapping approach to identify novel factors and a genetically-informed study design to account for genetic confounding. This project addresses ...

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Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Evaluating the role of common risk variation in the recurrence risk of schizophrenia in multiplex schizophrenia families

Schizophrenia (SCZ) is a severe, clinically heterogeneous psychiatric disorder with a population prevalence of ~1% [1]. Twin, family, and adoption studies consistently show a strong genetic component, with heritability estimates of around 0.75–0.80 [2,3,4,5,6], and family history (FH) remains the strongest risk factor for developing SCZ [7]. Despite high heritability, ~2/3 of SCZ cases report no FH of psychotic illness, and most subjects with a positive FH (FH+) report only a single affected relative [8, 9], concordant with the rates ...

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Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

Genome-wide analysis of schizophrenia and multiple sclerosis identifies shared genomic loci with mixed direction of effects

In the last decade, genome-wide association studies (GWAS) have identified a large number of common genetic risk variants associated with complex human phenotypes (Visscher et al., 2017). Many genetic variants identified by GWAS exhibit varying degrees of genetic pleiotropy (Solovieff et al., 2013), and investigating the nature of these shared genetic risks is important for improving our understanding of the etiology and underlying genetic architecture of complex human disorders. A widely used method for assessing the genetic relationship between two ...

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Postdoctoral Training in Psychiatric and Statistical Genetics

Postdoctoral Training in Psychiatric and Statistical Genetics

The Virginia Institute for Psychiatric and Behavioral Genetics is pleased to invite applications for postdoctoral training with a focus on mental health. The Institute offers a rich interdisciplinary training environment. Institute faculty include leaders in the fields of behavioral and psychiatric genetics and represent a wide range of scientific backgrounds from molecular and statistical genetics to epidemiology, psychology, and psychiatry.

Currently funded research at VIPBG includes molecular-genetic studies of schizophrenia, major depression, anxiety and panic disorders, PTSD, substance use disorders ...

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Genome Comparisons Reveal DNA Risk Variants Differ in People of East Asian vs. European Ancestry

Genome Comparisons Reveal DNA Risk Variants Differ in People of East Asian vs. European Ancestry

An analysis of multiple genome-wide studies making associations between depression and “risk” locations in the human genome has provided a vivid demonstration that results can vary substantially depending on the ethnicity and even country of origin of those whose genomes are being studied.

Members of the major depression working group of the Psychiatric Genomics Consortium and an international team of researchers that included 10 recipients of BBRF grants and prizes and two BBRF Scientific Council members, Kenneth S. Kendler, M.D., and ...

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Dr. Roberson-Nay Receives $275K NIMH R21 Funded Research Grant

Dr. Roberson-Nay Receives $275K NIMH R21 Funded Research Grant

Roxann Roberson-Nay, Ph.D. received a two year, $275K NIMH R21 grant for her “Quantification and Characterization of Bulk and L1CAM-Enriched Exosomal MicroRNA Cargo in Healthy Young People” research study.

Extracellular vesicles (EVs) are membrane-bound sacs that transport bioactive materials like proteins, DNA, and RNA. EVs are released from all (or nearly all) tissues into the bloodstream as a normal part of physiology. Because EVs easily cross the blood-brain-barrier, analyzing cell surface markers and biological cargo may enable researchers to ...

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